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originally posted by: thethinkingman
Thats way too much testing, so unnessicary. We all know that it doesnt work....those poor mice.
Omg guyz legit we've basically all had covid.......and are therefore as immune as can be .....GUESS YOU BETTER GET INJECTED AND HAVE SPIKE PROTEINS FLOATING ALL AROUND YOUR BODY IN MASSIVE QUANTITIES....im sure pfizers bank account is so sad right now.
It can't possibly be for money, right? Guaranteed taxpayer money......
originally posted by: v1rtu0s0
Nope. 1000% for your health. We all need super healthy spike proteins penetrating all tissues of our bodies 24/7. Even if we already have natural immunity and or are young enough to have a statistical ZERO risk from the current form of covid, we need this sh# PUMPED into us!
originally posted by: Xtrozero
originally posted by: v1rtu0s0
Nope. 1000% for your health. We all need super healthy spike proteins penetrating all tissues of our bodies 24/7. Even if we already have natural immunity and or are young enough to have a statistical ZERO risk from the current form of covid, we need this sh# PUMPED into us!
You get that every time you get COVID on a massive level, enjoy...
originally posted by: v1rtu0s0
But what I'm saying is we should all be getting boosters everyday.
So the muscle cells around the injection are hit by the vaccine (whether mRNA-containing lipid nanoparticles or adenovirus vectors) while a good portion of the remaining dose is in the intercellular fluid and thus drains through the lymphatic system, not the bloodstream. That's what you want, since the lymph nodes are a major site of immune response. The draining lymph nodes for the deltoid are going to be the deltoid/pectoral ones where those two muscles meet, and the larger axillary lymph nodes down in the armpit on that side.
originally posted by: v1rtu0s0
originally posted by: Xtrozero
originally posted by: v1rtu0s0
Nope. 1000% for your health. We all need super healthy spike proteins penetrating all tissues of our bodies 24/7. Even if we already have natural immunity and or are young enough to have a statistical ZERO risk from the current form of covid, we need this sh# PUMPED into us!
You get that every time you get COVID on a massive level, enjoy...
You don't have free floating spike proteins, they are attached to viruses. There are vastly more and they persist much much longer than with the virus, trillions of spike proteins floating around in all tissues of your body, waiting to cause inflammation anywhere for months and months because they replaced uridine with pseudouridine in the mRNA. No one knows how long they could last but some studies have shown at least 6 months.
But what I'm saying is we should all be getting boosters everyday.
Each RNA character weighs on the order of 0.53·10⁻²¹ grams, meaning there are around 6·10¹⁶ characters in a single 30 microgram vaccine dose. Expressed in bytes, this is around 14 petabytes, although it must be said this consists of around 13,000 billion repetitions of the same 4284 characters. The actual informational content of the vaccine is just over a kilobyte. SARS-CoV-2 itself weighs in at around 7.5 kilobytes.
originally posted by: Xtrozero
originally posted by: v1rtu0s0
But what I'm saying is we should all be getting boosters everyday.
I've gotten 29 since they are free and you never can be too safe, right?
The very nature of the spike protein is that they use the spikes to anchor the virus that is free roaming. Spike protein by itself will anchor more than not as that is the purpose of it such as mostly in the muscle tissue it was injected into. So pick you poison here, free roaming virus that is mass producing and ripping the crap out of cells in that process, or inert spike protein that anchor quickly with no other process.
So the muscle cells around the injection are hit by the vaccine (whether mRNA-containing lipid nanoparticles or adenovirus vectors) while a good portion of the remaining dose is in the intercellular fluid and thus drains through the lymphatic system, not the bloodstream. That's what you want, since the lymph nodes are a major site of immune response. The draining lymph nodes for the deltoid are going to be the deltoid/pectoral ones where those two muscles meet, and the larger axillary lymph nodes down in the armpit on that side.
But you know that...
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity.
To determine the mechanism, we analyzed the kinetics of induction of circulating exosomes with SARS-CoV-2 spike protein and Ab following vaccination of healthy individuals. Results demonstrated induction of circulating exosomes expressing spike protein on day 14 after vaccination followed by Abs 14 d after the second dose.
Exosomes with spike protein, Abs to SARS-CoV-2 spike, and T cells secreting IFN-γ and TNF-α increased following the booster dose. Transmission electron microscopy of exosomes also demonstrated spike protein Ags on their surface.
Exosomes with spike protein and Abs decreased in parallel after four months. These results demonstrate an important role of circulating exosomes with spike protein for effective immunization following mRNA-based vaccination. This is further documented by induction of humoral and cellular immune responses in mice immunized with exosomes carrying spike protein.
Coronavirus disease 2019 (COVID-19) mRNA vaccines induce robust immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yet their cellular/molecular mode of action and the etiology of the induced adverse events (AEs) remain elusive.
Lipid nanoparticles (LNPs) probably have a broad distribution in human tissues/organs; they may also (along with the packaged mRNA) exert a proinflammatory action.
COVID-19 mRNA vaccines encode a transmembrane SARS-CoV-2 spike (S) protein; however, shedding of the antigen and/or related peptide fragments into the circulation may occur.
Binding of circulating S protein to angiotensin-converting enzyme 2 (ACE2) (that is critical for the renin–angiotensin system balance) or to other targets, along with the possibility of molecular mimicry with human proteins, may contribute to the vaccination-related AEs.
Following vaccination, a cell may present the produced S protein (or its subunits/peptide fragments) to mobilize immune responses or be abolished by the immune system (e.g., cytotoxic T cells) [25. ]. Consequently, the debris produced, or even the direct secretion (including shedding) of the antigen by the transfected cells, may release large amounts of the S protein or its subunits/peptide fragments to the circulation
Other reports indicate that S protein triggers an inflammatory response signature in human corneal epithelial cells [107. ], increases oxidative stress and DNA ds breaks in human peripheral-blood mononuclear cells (PBMCs) postvaccination [108. ], and binds to lipopolysaccharide, boosting its proinflammatory activity [109. ,110. ]. Furthermore, S protein induces neuroinflammation and caspase-1 activation in BV-2 microglia cells [111. ] and blocks neuronal firing in sensory neurons [112. ]. The S protein-induced systemic inflammation may proceed via TLR2-dependent activation of the nuclear factor κB (NF-κB) pathway
originally posted by: thethinkingman
Except that excerpt is absolutely not true and totally trying to put across the vaccine can't possibly do anything wrong....thats insane.
We also demonstrated that the exosomes from vaccinated individuals were immunogenic and induced Abs to SARS-CoV-2 spike protein as well as T cell responses to spike protein Ag, suggesting that mRNA-based vaccination-induced exosomes with SARS-CoV-2 spike protein Ag will not only induce humoral immunity but also cellular immune responses.
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and protective immunity.
Its just dumb, how can you explain blood clots, myocarditis and the multiple other damaging effects caused from the vaccines???? There are multiple studies that show the spike protein being found around the body.
originally posted by: Xtrozero
originally posted by: v1rtu0s0
But what I'm saying is we should all be getting boosters everyday.
I've gotten 29 since they are free and you never can be too safe, right?
The very nature of the spike protein is that they use the spikes to anchor the virus that is free roaming. Spike protein by itself will anchor more than not as that is the purpose of it such as mostly in the muscle tissue it was injected into. So pick you poison here, free roaming virus that is mass producing and ripping the crap out of cells in that process, or inert spike protein that anchor quickly with no other process.
So the muscle cells around the injection are hit by the vaccine (whether mRNA-containing lipid nanoparticles or adenovirus vectors) while a good portion of the remaining dose is in the intercellular fluid and thus drains through the lymphatic system, not the bloodstream. That's what you want, since the lymph nodes are a major site of immune response. The draining lymph nodes for the deltoid are going to be the deltoid/pectoral ones where those two muscles meet, and the larger axillary lymph nodes down in the armpit on that side.
But you know that...
originally posted by: anonentity
a reply to: jerich0
Getting the population down to levels that suit the ones causing it has been so long in the planning, We must not forget the numbers which have to be achieved. Thank you to all those participating. www.bitchute.com...
OK that is what I said, not sure your point here?
The two most frequently used SARS-CoV-2 vaccines, from Pfizer/BioNTech [1] and Moderna [2], respectively, are both mRNA vaccines. The sequence of Pfizer/BioNTech’s BNT-162b2 is publicly available [3], and the sequence of Moderna’s mRNA-1273 has recently been sequenced [4]. Both mRNA encodes the same S-2P protein [5,6] which differ from the spike protein in the reference SARS-CoV-2 genome (NC_045512) by two amino acids, i.e., amino acids KV at sites 986 and 987 were replaced by PP to stabilize the resulting spike protein in the prefusion state to train the host immune system to recognize the virus before its entry into the host cell [7,8].
As mammalian host cells attack unmodified exogeneous RNA [12,13], all U nucleotides were replaced by N1-methylpseudouridine (Ψ) [14,15]. However, Ψ wobbles more in base-pairing than U and can pair not only with A and G, but also, to a lesser extent, with C and U [16]. This is likely to increase misreading of a codon by a near-cognate tRNA. When nucleotide U in stop codons was replaced by Ψ, the rate of misreading of a stop codon by a near-cognate tRNAs increased [17]. Such readthrough events would not only decrease the number of immunogenic proteins, but also produce a longer protein of unknown fate with potentially deleterious effects.
One might think that the consecutive stop codons in the two vaccine mRNAs would offer a fail-safe mechanism, given the readthrough observed in the translation of not only yeast genes but also mammalian genes [77,78,79]. For example, human MDH1 has a UGA stop codon that is often translated as Trp (encoded by UGG) or Arg (encoded by CGA and other synonymous codons) leading to an extended protein without frameshifting [77]. An additional in-frame stop codon is expected to prevent the production of such unintended proteins with potentially deleterious effects [80]. However, in many cases, misreading UGA stop codons in prokaryotes is associated with a +1 frameshift [81,82,83,84]. Such frameshifting also occurs in eukaryotes, such as the mammalian AZ1 gene with a stop codon context UGAU [85], where UGA is the stop codon followed by a U at the +4 site. The first U in the stop codon in translating AZ1 mRNA is often skipped when the concentration of polyamines is high, resulting in the ribosome reading GAU as the next codon [85]. With such a +1 frameshifting, a downstream in-frame stop codon cannot serve as a fail-safe mechanism. UGA is a poor choice of a stop codon, and UGAU in Pfizer/BioNTech and Moderna mRNA vaccines could be even worse.
Although testing is a key component of viral safety in biotechnology products, the data presented here indicate that testing alone is not enough to ensure that a given product is free of a viral contaminant, and that a holistic, multifaceted approach must be taken. This is never more true than when faced with a previously unknown emerging virus, such as SARS-CoV-2, where the capacity of the virus to infect production cell lines or be detected in existing assays is not initially known. Some approaches, such as the implementation of rapid PCR tests for forward processing decisions, have been shown to enhance containment and prevent the spread of a contaminating virus to other parts of the manufacturing facility. We believe that collective effort and shared knowledge can ensure the continued success of the life-saving therapies of today and tomorrow.
As transformational as the genetics revolution of the past decades has been, at its heart has always been a mystery: proteins. A gene is simply the code for making a single protein. In that gene, a set of three DNA nucleotides, represented by letters, yields one amino acid, and another triplet codes for a different amino acid. There are 20 amino acids that a cell can use as protein-building blocks, and each one has a unique shape and function. Some are more flexible than others. Some are positively charged, some negative. Some are attracted to water; others are repelled by it.
All day long our cells churn out new proteins in the exact order of amino acids dictated by our genetic code, and the proteins spontaneously snap into shape. That shape, along with the charges of the atoms on the exposed bits, determines the function: what they respond to, what they attach to, what they can do. When we say, “He has the gene for red hair,” it means he has the blueprint for proteins that lead to a particular kind of pigment. When we say, “She has a gene that causes breast cancer,” it means she has a mutation in a gene that causes its protein to be made with an incorrect amino acid, which screws up its function in a way that can lead to cancer.
Understanding the mechanics of protein folding would allow us to design new classes of drugs that could hobble or replace proteins gone wrong and to probe the etiology of diseases such as Alzheimer’s, Parkinson’s, Huntington’s and cystic fibrosis, which are linked to misshapen proteins.
Unfortunately, because proteins are so small, it is almost impossible to tell what is happening in this nanoworld, even with powerful microscopes. We do not know precisely how all of these proteins fold correctly, much less what goes wrong when they misfold. It can take a year and $120,000 to produce a high-resolution image of one protein on specialized equipment. We currently know the structures of just 0.1 percent of them. For the rest, we guess. That is why there is a mystery at the center of the genetics revolution: Certain genetic sequences are associated with physical and mental effects, but often we cannot tell why. We have lacked the Rosetta stone of protein structure to translate between the starting point of genes and the end point of bodily functions.
In theory, it should be possible to predict the final structure of a protein from its genetic sequence—a task so essential to our understanding that in 2005 Science magazine included it in its 125th-anniversary issue’s list of the most important unanswered questions in science. But in reality, it has been possible for only a very few extremely simple proteins. For example, scientists know that if they want to build a straight helix (a common Slinky-like structure in proteins that provides stability), they can use amino acids such as leucine, alanine and glutamate, which have the right curve and complementarity to form regular spirals and bond tightly to the amino acids on the coil above or below them. If scientists want a kink in their Slinky, they can add a proline, which does not form a bond and allows the rest of the helix to bend away from it.
originally posted by: thethinkingman
This stuff is happening in real time literally trillions of your cells are doing stuff and "science" observes that stuff which happens in nanoseconds, miliseconds, minutes in the time frame or years, decades and centuries....... from my research theres something 8 million qualified research scientists in the entire world which is about 0.1% of the world population and theres around 98 million people with phd's and masters which is around 1% of the population.