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ID CA134_HUMAN Reviewed; 83 AA... DE RecName: Full=Putative uncharacterized protein C1orf134; DE Flags: Precursor; GN Name=C1orf134; OS Homo sapiens ...
DR PRIDE; Q5TEV5; -. DR ProteomicsDB; 65065; -. DR GeneCards; C1orf134; -. DR HGNC; HGNC:32021;... C:extracellular region; IEA:UniProtKB-SubCell. PE 3: Inferred from homology; KW Complete proteome; Glycoprotein; Reference proteome; Secreted; Signal. FT SIGNAL 1 20 [ECO:0000255]. FT CHAIN 21 83 Putative uncharacterized protein FT.
Signal peptides are found in proteins that are targeted to the endoplasmic reticulum and eventually destined to be either secreted/extracellular/periplasmic/etc., retained in the lumen of the endoplasmic reticulum, of the lysosome or of any other organelle along the secretory pathway or to be I single-pass membrane proteins.
The regulated secretory pathway provides critical control of peptide, growth factor, and hormone release from neuroendocrine and endocrine cells, and neurons, maintaining physiological homeostasis.
Neurotrophic growth factors, hormones, peptide precursors, prohormone convertases, granins, and other DCG proteins are secreted through the regulated or constitutive secretory pathways. Even relatively subtle changes in protein processing, levels, or regulated secretion, due to specific SNPs that impact a variety of proteins in the secretory pathway, have been reported to be associated with neuropsychiatric or metabolic disease.
Tay-Sachs disease ... the child usually lives only until age 4 or 5.
Gaucher disease (bone pain, enlarged liver, and low platelet counts, often mild, in children or adults)
Fabry disease (pain in the extremities in childhood, with kidney and heart disease and strokes in adulthood; only males are affected.
Krabbe disease (progressive nerve damage, developmental delay in young children; occasionally adults are affected).
Friedreich Ataxia causes nerve damage and often heart problems. Inability to walk usually results by young adulthood.
originally posted by: purplemer
I dont think snake venom would work if ingested.
TUCSON, AZ — Snakes are starting to play a big role in COVID-19 research. Scientists from the University of Arizona have discovered an enzyme, similar to one found in rattlesnake venom, that could be driving COVID-19 deaths.
"We found evidence that there was an enzyme, a snake-like enzyme, in the blood of people who were in extraordinarily high levels,” says Dr. Floyd Chilton, the senior author of the study with the University of Arizona, College of Agriculture and Life Sciences.
The snake-like enzyme is found in healthy people at low levels to prevent bacterial infections. In severe cases of COVID-19, it’s doing the opposite.
"These high levels of this enzyme are looking at those tissues in the organs and saying, ‘you look like a bacteria, let's shred your membranes. Let's put these organs out of their misery,’" says Dr. Chilton.
How poisonous is a golden lancehead?
A bite from a golden lancehead carries a seven percent chance of death, and even with treatment, victims still have have a three percent chance of dying. The snake's venom can cause kidney failure, necrosis of muscular tissue, brain hemorrhaging and intestinal bleeding.Jun 25, 2014
originally posted by: SeaWorthy
originally posted by: purplemer
I dont think snake venom would work if ingested.
that's why you have to let them bite you.
I
TUCSON, AZ — Snakes are starting to play a big role in COVID-19 research. Scientists from the University of Arizona have discovered an enzyme, similar to one found in rattlesnake venom, that could be driving COVID-19 deaths.
"We found evidence that there was an enzyme, a snake-like enzyme, in the blood of people who were in extraordinarily high levels,” says Dr. Floyd Chilton, the senior author of the study with the University of Arizona, College of Agriculture and Life Sciences.
The snake-like enzyme is found in healthy people at low levels to prevent bacterial infections. In severe cases of COVID-19, it’s doing the opposite.
"These high levels of this enzyme are looking at those tissues in the organs and saying, ‘you look like a bacteria, let's shred your membranes. Let's put these organs out of their misery,’" says Dr. Chilton.
www.abc15.com...