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The International Chemical Secretariat (ChemSec) announced on November 14, 2019, that it added more chemicals, including carbon nanotubes, to its Substitute It Now! (SIN) List. ChemSec describes carbon nanotubes as “one of the more well-studied nanomaterials” and notes that “they are used to make durable, lightweight materials, for electrical conductivity, ...” Dr. Anna Lennquist, Project Manager for the SIN List at ChemSec, states: “Several studies have shown that carbon nanotubes cause lung cancer. The small tubes induce inflammation in a somewhat similar way to asbestos."
The polynucleotides, primary constructs or mmRNA of the invention can be attached or otherwise bound to at least one nanotube such as, but not limited to, rosette nanotubes, rosette nanotubes having twin bases with a linker, carbon nanotubes and/or single-walled carbon nanotubes...
As a non-limiting example, the length of the nanotubes may be altered to hinder the nanotubes from passing through the holes in the walls of normal blood vessels but still small enough to pass through the larger holes in the blood vessels of tumor tissue.
These results show that functionalized biomimetic RNTs provide a support for neurite growth and extension and have the ability to modulate neuronal morphology. These results also pave the way for the design of injectable RNT-based nanomaterials that support guided neural regeneration following traumatic injury.
Corona phase molecular recognition (CoPhMoRe) is a phenomenon whereby a polymer or surfactant corona phase wrapped around a nanoparticle selectively recognizes a particular molecule. The method can potentially generate non-biological, synthetic molecular recognition sites, analogous to antibodies, for a broad range of biomedical applications, including new types of sensors,... In this work, we utilize near infrared fluorescent single-walled carbon nanotubes wrapped with specific single stranded DNA sequences to explore the (n,m) chirality dependence of CoPhMoRe.
Absorption/binding of coagulation factors onto nanoparticle surfaces may have two consequences: inactivation of the factors or reduced availability to other components of the coagulation cascade; or contact activation of the factors. The former may cause prolongation or deficiency in coagulation reactions, while the latter may cause undesirable coagulation. Nanoparticles’ physicochemical properties determine their effects on coagulation. For example, coagulation factor XII can undergo self-activation after interaction with an anionic surface.
Previous work by OBRR scientists (Semberova J. et al., NanoLetters 2009) provided the following insights into CNT activation of platelets: Various CNTs induce human platelets to aggregate and release of platelet membrane microparticles. CNT-induced platelet aggregation is dependent on the influx of extracellular Ca , a process that is sensitive to Ca entry inhibitors.
Calcium-induced clotting of platelet-rich but not platelet-poor plasma induced VEGF release with a proportional response between platelet count and VEGF level and isolated platelets released significant quantities of VEGF.
The present study identifies the intestinal mucosa as one of the origins of the elevated VEGF serum levels in patients with active inflammatory bowel disease and verifies the findings of recent studies about the importance of VEGF in Crohn's disease and ulcerative colitis.
Continued next reply.
edit on 2-4-2022 by Wisenox because: Condensed wording.
Because of its importance in tumor formation and survival, several medications have been developed to inhibit VEGF and reduce blood vessel formation in cancer. ...they have been shown to cause side effects such as hypertension, artery clots, complications in wound healing, and, more rarely, gastrointestinal perforation and fistulas.