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Imagine a cure that’s as contagious as the disease it fights—a vaccine that could replicate in a host’s body and spread to others nearby, quickly and easily protecting a whole population from microbial attacks. That’s the goal of several teams around the world who are reviving controversial research to develop self-spreading vaccines.
Their hope is to reduce infectious disease transmission among wild animals, thereby lowering the risk that harmful viruses and bacteria can jump from wildlife to humans as many experts believe happened with SARS-CoV-2, the virus that caused the COVID-19 pandemic.
Each of these new vaccines are so-called recombinant viruses. Researchers first identify a protein from the target microbe that serves as an antigen—a substance that triggers immune responses in vaccinated people or animals. Then the researchers select a virus to carry the vaccine and spread it. To do this, researchers capture a few animals from their target population—primates for Ebola, rats for Lassa fever—and isolate a virus that naturally infects those animals. Then they splice in genetic material from the target to create a vaccine.
“Our understanding of infectious disease dynamics in wildlife remain for the most part too simple to meaningfully predict the outcome of such an intervention…
…the myxoma virus that had become such a devastating challenge in Europe arose because a man in France intentionally released the virus in 1952 to keep rabbits out of his home garden.
there is an emerging understanding that viruses and bacteria exist in complex microbial ecosystems, perhaps keeping each other’s populations in check. The impact of a self-spreading vaccine that wipes out one specific virus might have unknown consequences.
Dramatically shifting the balance by attempting to eradicate or reduce an endemic virus in nature could risk the emergence of other pathogens which impact both the wildlife species themselves, as well as people and our domestic animals…
“You don't need to be a Rhodes scholar to work out that people will be nervous about a disseminating viral vector. It's a concept that will scare people,” says Redwood. “The way that I like to think about it is that it may never be used, but it's better to have something in the cupboard that can be used and is mature if we need it. And to say, ‘Let's just not do this research because it's too dangerous,’ to me, that makes no sense at all.”
Washington isn't Raccoon city. In the real world you have to jump through all kinds of hoops with ethics committees just to get approval to do lab based studies, and even if you can get permission to do a limited study it can be extremely difficult to get funding as most of the big foundations that fund research have their own ethics committees as well as one eye on public relations.
originally posted by: AaarghZombies
a reply to: TDDAgain
These things are extremely heavily regulated.
originally posted by: TDDAgain
a reply to: AaarghZombies
Define "these" things.
I spoke about AI, not regulated.
I spoke about GMO, if regulations were in place, it did not stop them
I spoke about releasing GM mosquito, if regulations were in place, it did not stop them
I spoke about the OP, if regulations are in place...
you get it or not.
originally posted by: xuenchen
originally posted by: AaarghZombies
a reply to: TDDAgain
These things are extremely heavily regulated.
Sure they are. Sure they are. 🤫
These things are extremely heavily regulated.