Vaccine Immunodeficiency Theory

I was watching an interview where the subject of Vaccine Acquired Immunodeficiency Syndrome (COVAIDS) was being discussed.  Specifically, I was curious about the drop in CD4 counts.
This made me wonder how the immune deficiency could be occurring.  So, I thought of a possible theory and put it into a  graphic.

To understand the graphic, I will briefly cover the concepts of: Macrophage Polarization, Fcabs, Bi-Conjugates, PEGylation and Flow Cytometry.

1. Macrophage Polarization
"Macrophages are specialised cells involved in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In addition, they can also present antigens to T cells and initiate inflammation by releasing molecules (known as cytokines) that activate other cells."

Why macrophages then?

Macrophages and especially the liver-resident Kupffer cells are in the focus of nanomedicine due to their highly efficient and unspecific uptake of most nanomaterials as well as due to their critical pathogenic functions during inflammation and fibrogenesis. The mannose receptor enables targeting macrophages in liver disease, but macrophages can also become activated by certain nanomaterials

Therapeutic targeting of liver inflammation and fibrosis by nanomedicine

These cells can become activated through polarization.  Activated cells are known as M1, responsible for immunity, and M2, resonsible for repair:



So, if the cell is activated as M2, then proinflammatory and immune responses aren't rendered.  Immunodeficiency is occurring.

Dysregulation of the macrophage polarization process can also lead to adverse effects in some unexpected ways, including dusrupting pregnancy:

In abnormal pregnancy, more classically activated (M1) macrophages have been observed at the maternal-fetal interface. The balance of polarization between M1 and M2 macrophages is important for various processes of normal pregnancy, such as trophoblast invasion, spiral artery remodeling, and apoptotic cell phagocytosis. Conversely, the dysregulated polarization of macrophages was associated with inadequate remodeling of the uterine vessels and defective trophoblast invasion and finally led to spontaneous abortion, preeclampsia and preterm birth.

Suk, Jung Soo et al. “PEGylation as a strategy for improving nanoparticle-based drug and gene delivery.” Advanced drug delivery reviews vol. 99,Pt A (2016): 28-51. doi:10.1016/j.addr.2015.09.012



2. Fcabs
"Fcab means a constant domain of an Antibody that includes an antigen binding site that confers a specific binding of such constant domain to a defined target antigen."



Ordinarily, the Fc portion of an antibody binds with Fc receptors on cell surfaces.  Fcabs allow for the binding portion to be customized to bind with antigens.  For example CD4 antigens:



3. Bi-Conjugates
Bi-conjugates are a combination of a 'linker' and a PEG/PEO conjugate, in this image the conjugate is IL-4, which has the effect of polarizing to M2 activation:


The linker is later removed through enzymes or other methods.

4. Pegylation
What does the PEGylation accomplish?

To prevent the attachment with serum proteins, many nanoparticles including gold-based systems are PEGylated to reduce their unspecific uptake by phagocytes by evoking a neutral charge.

Therapeutic targeting of liver inflammation and fibrosis by nanomedicine
Pegylation will deactivate M1 cells.

5. Flow Cytometry
Flow cytometry is the laboratory method used to obtain CD4 counts, which are often used in HIV diagnosis.  The assay work by attaching synthetic beads or dyes to antibodies specific for CD4 antigens on macrophage cell surfaces.
The pair are then sent through a flow chamber where lasers scatter light off of the beads and dyes.  The scattering is then interpreted into a count of CD4 cells:



It should be noted that flow cytometry only works if antigens are available for the test antibodies to attach to.  This will be illustrated when we put it all together:



As I mentioned at the beginning of the post, this is just a possible theory to explain the immunity loss and equivalency to HIV.  The theory does, however, provide a possible link to adverse effects on pregnancy and the immune system deficiency with decreased CD4 counts. Flow cytometry could be missing the bound CD4 antigens resulting in patients being treated under an HIV diagnosis code.  Some treatments, of which, may cause additonal concerns for the patient.  

a reply to: Wisenox

Out of all of that, the only thing my peon brain understood was “drugs are bad mmmkay”

But thanks for putting the time and effort into this, very well done!

Unless you live a REALLY underground bunker terrified, not on this earth life, almost everyone you know has been vaccinated. Statistically none of them had any reactions beyond a sore injection spot.

originally posted by: LordAhriman
Statistically none of them had any reactions beyond a sore injection spot.

And a new unassigned bluetooth mac address signal.

(sarcasm)?

originally posted by: Brotherman
a reply to: Wisenox

Out of all of that, the only thing my peon brain understood was “drugs are bad mmmkay”

But thanks for putting the time and effort into this, very well done!

Same here But bookmarked at least .

originally posted by: LordAhriman
Unless you live a REALLY underground bunker terrified, not on this earth life, almost everyone you know has been vaccinated. Statistically none of them had any reactions beyond a sore injection spot.

I haven't , nor has my elderly mom (who never got covid). And of the few that had the 'vaccine' they have had repeated bladder infections one also repeated rashes.

Just because they symptoms arent immediate, as in months to a year, doesn't mean no damage has been done....nobody has any clue as to the long term results of this....nobody.


a reply to: ancientlight

Sounds impressive, but I am too tired to go through it and verify the conclusions tonight. Hopefully I will have a chance tomorrow to go through it...meaning I hope I remember the thread so I can go through it. I understand half of the stuff but do not know if this is the right conclusion on method of action. I have read some articles on how that stuff worked, but have not actually studied how to apply any of it. The OP does look like it could be a relevant theory as to how it works, but I cannot say if it is right or wrong because it exceeds my knowledge I have on this right now.

originally posted by: LordAhriman
Unless you live a REALLY underground bunker terrified, not on this earth life, almost everyone you know has been vaccinated. Statistically none of them had any reactions beyond a sore injection spot.

My Covid lacky Alarm is going off

LordAhriman !

Just playing mate , but seriously I know several people with out of control High blood pressure after the Vaccine .

The Vaccine is causing problems mate look the other way if you want .

a reply to: Wisenox

Thank you for all of the work, great post. I think my wife will be able to explain it to me but I got some of it.

a reply to: LordAhriman

I interact with a lot of people at work. A few hundred daily but varied people depending on shifts.

People are sicker. That’s my observation.
I wish they weren’t.

People are dropping dead

a reply to: LordAhriman

I actually only know of a handful of folks that received innoculations, and they cannot seem to get unsick. It's like they have been in a perpetual state of illness, either mild or requiring days off from work since taking experimental drugs through coersion and intimidation.

Thankfully many of us non-conformist types refused to be intimidated and coerced or peer pressured into just doing what's trendy cuz everyone is doing it and are carrying on just fine.

originally posted by: neomaximus10
Just because they symptoms arent immediate, as in months to a year, doesn't mean no damage has been done....nobody has any clue as to the long term results of this....nobody.

And now here is where the fear porn goes... As billions get vaccinated and the Nostradamus level of predictions that people will drop like flies doesn't happen we are down to my heart will explode in ten years.

I'm really thinking the Cigar I smoked for an hour and a half and the nice big glass of 18 year-old scotch will do more harm in the long run than the vaccine. So lets do a poll as to what will get my liver first...

18 year-old scotch
The vaccine

originally posted by: visitedbythem
People are dropping dead

The biggest problem with living is no one makes it out alive. I bet in 2050 when the average life expectancy is 95 and SS doesn't kick in until you are like 80 people will be bitching about how big pharma is trying to kill them...lol

originally posted by: Wisenox
I was watching an interview where the subject of Vaccine Acquired Immunodeficiency Syndrome (COVAIDS) was being discussed.  Specifically, I was curious about the drop in CD4 counts.

The biggest issue is that VAIDS is a made up symptom from reddit/twitter. There really is no such thing, and though you have a theory it is not seen in the billons of vaccinated people. This is not to say there are no real side effects that also happen to be rare, but I think we are now at the point in the huge number of people actually vaccinated and the time duration of a year or more that the side effects are pretty much established.

a reply to: Xtrozero

The side effects I was attempting to account for are the drop in CD4 count and the reported loss in immunity.
The loss of immunity symptom could be referring to the lack of CD4 antigens found in flow cytometry tests, so they could actually be the same.

In regard to the Fcab antibody, the patent beats around the bush a bit, but the description is of Fcab chimeric antibodies. This explanation would go with the Fcab section in the OP:

The monoclonal antibodies herein specifically include "chimeric" antibodies (immunoglobulins) in which a portion of the heavy and/or light chain is identical with or homologous to corresponding sequences in antibodies derived from a particular species or belonging to a particular antibody class or subclass, while the remainder of the chain(s) is(are) identical with or homologous to corresponding sequences in antibodies derived from another species or belonging to another antibody class or subclass, as well as fragments of such antibodies, so long as they exhibit the desired biological activity. Chimeric antibodies of interest herein include, but are not limited to, "primatized" antibodies comprising variable domain antigen-binding sequences derived from a non-human primate (e.g., Old World Monkey, Ape etc.) and human constant region sequences.

An "antibody fragment" comprises a portion of an intact antibody, preferably the antigen binding and/or the variable region of the intact antibody. Examples of antibody fragments include Fab, Fab', F(ab').sub.2 and Fv fragments; diabodies; linear antibodies; nanobodies; single-chain antibody molecules and multispecific antibodies formed from antibody fragments.

Any of the five classes of immunoglobulins, IgA, IgD, IgE, IgG and IgM, may be encoded by the mmRNA of the invention, including the heavy chains designated alpha, delta, epsilon, gamma and mu, respectively.

It seems, to me, that the chimeric Fc portion is part Fc constant from humans conjugated with highly specific antigen binding portions of primate antibodies.
They could have chosen the primate antigen because it may have a higher affinity for the CD4 antigen than human derived antibodies.

originally posted by: Xtrozero
I bet in 2050 when the average life expectancy is 95 and SS doesn't kick in until you are like 80

Is that short sightedness, or an abnormal interest in elite nazi regiments?

originally posted by: LordAhriman
Unless you live a REALLY underground bunker terrified, not on this earth life, almost everyone you know has been vaccinated. Statistically none of them had any reactions beyond a sore injection spot.

It takes around 5 to 10 years for HIV to turn into AIDS right? I’m not underground, never have been, nor have I had their poison. Well, except non-Symptomatic COVID. Not even a sneeze or a tickle, and they screwed up the world for it.
Keep cheering them on, I’m sure a few here will be giddy slapping on the chains.