Using old vaccine and dealing with new strains?

All the vaccine now is 2 years old calibrated for the original configuration. As you know, fuzzballs mutate at a rate 1 million times faster than people. It took fuzzballs 10 years to diverge to 96% genetically identical. That is to say, the original covid-19 strain diverged from its closest bat relative in Laos 10 years ago and were 96% genetically identical when it was diagnosed in December 2019. By comparison, it took humans and chimps 10 million years, 1 million times as long, to diverge to 96% genetically identical. The concept of original antigenic sin is what worries scientists. It is what is responsible for poor efficacy of the annual flu shot against flu. I quote the following article.

A research team led by Dr. Margaret E. Ackerman has observed elevated cross-reactive antibodies to endemic coronaviruses (CoVs), particularly to β-CoV OC43, in severe acute respiratory coronavirus 2 (SARS-CoV-2) natural infection cohorts when compared to naive controls. Pre-existing antibodies to endemic CoVs that cross-react with SARS-CoV-2 have the potential to influence the antibody response to the SARS-CoV-2 vaccination and infection. The magnitude of cross-reactive antibodies found in the current study published on the medRxiv* preprint server correlated well with responses to the SARS-CoV-2 spike protein and the S2 subdomain.

source: Evidence antibodies targeting HCoV-OC43 are robustly boosted in response to SARS-CoV-2 but not vaccination

Therefore, using the same old vax year after year will not be effective with mutated fuzzballs, because it triggers defense against the original strain which has been extinct for nearly 2 years already.

a reply to: ResistanceFighter

You are misinformed. The flu virus arrives SGEMENTED into the cell. That means, when the flu cell membrane comes in contact with the cell wall to infect it, it them dissembles and enters the cell in 4 pieces. Lets call them A1, A2, A3, A4. Those 4 parts are reassembled in the cell and the instructions turn it into a viro-cell which then manufactures more virus, and stops doing the original job the cell had.

The problem with the flu is that you can have two variants at the same time. Which combination of variants depends on statistical spread and where you live. When someone sick with one strain catches another strain, both of those strain will likely encounter each other in the same cell. When that happens, you can get this. SO strain 2 is B1, B2, B3, B4. You get something like B1, A1, B3, A4. You dont really know until it happens. The probability of which strain will come out is how they decide which flu shot to make. It is based on the strains they thing are most prevalent, and which strains they are likely to interreact with.

Assuming COVID came from nature is also ill informed. The source they claim is natural that appeared in Wuhan they claim is from over 500 miles away. So their argument is that between its capture, and being eaten, no one came into contact with this animal. Also, they want you to believe that they are brining live animals to the Whian market frm 500+ iles away, because we are supposed to think people would buy them at the insane increased cost.

All that aside. The Wuhan Wet market they blamed was about 800 Yards from the Wuhan Lab that specialized in Coronaviruses. To believe it came from an animal hundreds of mile away, that had fist of a kind interaction with other animals creating this new strain, and not the lab hundreds of yards away where workers would have interacted with locals is a special type of gullible.

a reply to: ResistanceFighter

Be careful comparing two different viruses, but you are correct that all viruses mutate. They enter the cell very differently in regards to their genome. Both do undergo antigenic drift in which nucleotides are changed individually and the genome drifts slowly from the original template. Coronavirus is unique in that it has a protein complex that slows this process down, less chance of mutation but an increased chance that those mutations will be maintained in future generations. This also means attenuation is slower than we would see in other respiratory viruses.

Influenza mutates very quickly. This is because it’s genome is different in structure. A coronavirus is positive sense meaning it makes sense to the cell and can be used as mRNA for translation. Influenza is segmented into 8 components or segments and antisense, meaning that in its form it does not make sense to the cell. Our cells cannot recognize antisense RNA to copy or translate it, we just identify it as foreign and destroy it. It brings its own protein printer/copier called RdRp to copy the genome into mRNA and to create copies of the genes for new virus.

Because the genome is segmented, it can undergo something called antigenic shift. This is a shift or major change from the original virus. Influenza signals for 1 gene segment to be surrounded by 7 other RNA segments. Each segment is generated separately and then recombined into a new virion. Some segments like the 3 that encode for polymerase are very similar or conserved so that isn’t an issue if they are switched out. Others like HA, NA, or Pb can cause changes if they were switched out with another.

So you have influenza from a human and influenza from a bird that meet up and coinfect a pig. Because two viruses infect the same cell, packaging can now draw from 16 segments instead of 8 and you can have a novel virus easily created from those segments. Especially if HA, NA, or Pb are switched around. This is why you see H1N1 or H5N3 etc. when referring to the flu, there’s much more going on at a deeper level but it’s unimportant. The important thing here is antigen targets are changed and your cells no longer recognize their previous targets.

Cross reactive T-cells and cross reactive B-cells (antibodies) are important in coronavirus because of these differences from influenza. With the SARS like coronaviruses or betacoronaviruses, many of these antigen targets in the spike protein or the replicase complex are evolutionarily maintained because if they are lost, the virus can’t reproduce. So you have antibodies or cytotoxic T cells that recognize these conserved sites and immunity is expressed across several viruses.

With influenza and especially neuraminidase or hemagglutinin, these sites completely change and our cells lose immunity to the new variants/strains while still having immunity to old virus. When our cells recognize these epitomes or protein/antigen segments presented in MHC or on the virus, the virus can still infect our cells but cannot be released from sialic acid / NA interactions to infect other cells or is blocked from receptor binding and then bound and broken down. Influenza viruses go extinct more quickly because of this whereas coronavirus does not.

The Best Way To Defeat COVID Liars, Cheaters Is Challenging Them To Take Oath In Religious Sacred Sites
Source: saviorscyber.wordpress.com

We are living in a world with too much liars, cheaters, the total number of “stupid bad” low-level people number is out-weight the “good smart” high-level people number.

It is such a waste of time to debate with those stupid people.
The best and fastest way to find out the truth, to find out who is “correct”, who is “wrong” is gambling in front of many sacred religious sites.

Nobody can “made up” the old sacred temples, shrines, churches that exist from thousands year till today.

It is very easy to “marketing” and get attention from the public.
All you need to do is setup a group and challenging all the people/group/entities you think are liars, cheaters, deceivers to take oath, take swear till death in many old sacred religious sites all around the world and from as many different religions as possible. Because they “possible” control few location but they cannot all the world !

Example:
The current on going corona virus COVID virus pandemic have 2 groups with 2 ideology:
– 1 say vaccine is “good” and it is the only way to go.
– 2 say vaccine is “bad”, it is about human immune system that matter.

Both group go to at least 10 popular sacred sites from all various religions from all around the world to take the “gambling”.
Because the battle now is about “vaccine” and “human immune system”.

So the one with pro-vaccine must say take oath: “I/We willing to using COVID vaccine and let my immune system off/disappear because vaccine is better than human immune system, hey God let’s remove my human health immune system, Vaccine is enough”.

While the other group must say/take oath: “I/We never using vaccine because without human immune system, you cannot survive any kind of virus including the COVID, hey God let’s empower my human health immune system because that’s the best way to protect ”.

That’s is a basic simple oath example.
There could be more like “promise didn’t not hide any corona virus COVID information from the public, promise do not using COVID like a weapon with the public, promise do not take any idea/strategy from any other secret group but “manage” the COVID event and give out public policy base by 100% self-decision”.
Sorry folks, I don’t think any national leaders have gut to take that oath in many popular sacred religious sites because they would crushed and die instantly by higher level beings God within few days !

You can using similar format to challenge others in many different subjects in life, too.

Remember, do not waste time to “debate” if they do not willing to listen and have opened mindset. Just using “gambling” to settle everything, and gambling in front of religious God and natural God are the only way to go !

Best Regard,
The Savior From Cyber

Source: saviorscyber.wordpress.com

ATS has a rat problem I see

a reply to: SaviorCyberLegend