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Daszak: ...and we have now found, you know, after 6 or 7 years of doing this, over 100 new sars-related coronaviruses, very close to SARS... Some of them get into human cells in the lab, some of them can cause SARS disease in humanized mice models and are untreatable with therapeutic monoclonals and you can’t vaccinate against them with a vaccine. So, these are a clear and present danger….
Interviewer: You say these are diverse coronaviruses and you can’t vaccinate against them, and no anti-virals — so what do we do?
Daszak: Well I think…coronaviruses — you can manipulate them in the lab pretty easily. Spike protein drives a lot of what happen with coronavirus, in zoonotic risk. So you can get the sequence, you can build the protein, and we work a lot with Ralph Baric at UNC to do this. Insert into the backbone of another virus and do some work in the lab. So you can get more predictive when you find a sequence. You’ve got this diversity. Now the logical progression for vaccines is, if you are going to develop a vaccine for SARS, people are going to use pandemic SARS, but let’s insert some of these other things and get a better vaccine.
Biodefense and Emerging Infectious Diseases (BioD)
The goals of this mission area are to better understand how these deliberately emerging (i.e., intentionally caused) and naturally emerging infectious agents cause disease and how the immune system responds to them.
originally posted by: TzarChasm
Friendly reminder that the national institute of allergies and infectious diseases (NIAID) proudly declares their intentions up front.
Biodefense and Emerging Infectious Diseases (BioD)
The goals of this mission area are to better understand how these deliberately emerging (i.e., intentionally caused) and naturally emerging infectious agents cause disease and how the immune system responds to them.
In other words, the pandemic has always been an inevitable consequence of their job description since the program was initiated. It was only a matter of time.