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There is so far no scientifically validated evidence that directly supports a natural origin.
Although considerable evidence supports the natural origins of other outbreaks (eg, Nipah, MERS, and the 2002–04 SARS outbreak) direct evidence for a natural origin for SARS-CoV-2 is missing. After 19 months of investigations, the proximal progenitor of SARS-CoV-2 is still lacking. Neither the host pathway from bats to humans, nor the geographical route from Yunnan (where the viruses most closely related to SARS-CoV-2 have been sampled) to Wuhan (where the pandemic emerged) have been identified.
More than 80 000 samples collected from Chinese wildlife sites and animal farms all proved negative.
A research-related origin is plausible. Two questions need to be addressed: virus evolution and introduction into the human population. Since July, 2020, several peer-reviewed scientific papers have discussed the likelihood of a research-related origin of the virus.
Some unusual features of the SARS-CoV-2 genome sequence suggest that they may have resulted from genetic engineering, an approach widely used in some virology labs. Alternatively, adaptation to humans might result from undirected laboratory selection during serial passage in cell cultures or laboratory animals, including humanised mice.
Mice genetically modified to display the human receptor for entry of SARS-CoV-2 (ACE2) were used in research projects funded before the pandemic, to test the infectivity of different virus strains. Laboratory research also includes more targeted approaches such as gain-of-function experiments relying on chimeric viruses to test their potential to cross species barriers.
originally posted by: chr0naut
a reply to: infolurker
lol.
Here's an 'out-there' idea:
Imagine if a disease that seems specifically adapted to one species on the planet, actually arose in that species?
Imagine it was a relatively benign and not particularly infectious cold virus, slightly related to a couple of similar but more dangerous viruses, but this one was really mild, so no-one gave it much mind, and one day it acquired a few mutations that made it more infectious and dangerous at the same time.
originally posted by: network dude
originally posted by: chr0naut
a reply to: infolurker
lol.
Here's an 'out-there' idea:
Imagine if a disease that seems specifically adapted to one species on the planet, actually arose in that species?
Imagine it was a relatively benign and not particularly infectious cold virus, slightly related to a couple of similar but more dangerous viruses, but this one was really mild, so no-one gave it much mind, and one day it acquired a few mutations that made it more infectious and dangerous at the same time.
Oh bootlicker, your persistence is admirable. Yes, your theory would be wonderful, until you mention the part where it surfaced in WUHAN CHINA, right next to a VIROLOGY lab that takes benign bat viruses and changes their molecular structure to make them more transmissible in humans and more deadly. Once you bring that part into the story, even the really, really, and I do mean really, stupid kids have to start to question things. But I totally get why you don't.
originally posted by: trentforce
The reason it is man made is very simple. It's got fusion cleavage sites which even remotely related coronaviruses don't have. Only some of the most distantly related coronaviruses have fusion cleavage sites. So how did these happen to be in this virus? The only explanation is GOF.
originally posted by: shooterbrody
Seems some won't accept its the kung flu.
Made in china.
Intentionally released by china.
But hey black market kfc is the way to go; when your whole nation is locked down.
originally posted by: sciencelol
So who attacks China 1st?
originally posted by: ihavethepower
a reply to: chr0naut
From the outset it is very infectious in humans but not infectious in any other animal species. Chance for this happening naturall is very astronomically small.