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Nicotine can selectively reduce the inflammatory response in various infection states, including Legionella pneumophila and Chlamydia pneumoniae infection, via the cholinergic anti-inflammatory pathway [6]. Nicotine is an agonist at the α7 subunit of nicotinic acetylcholine (α7-nACh) receptors on innate immune cells such as macrophages. These receptors respond to acetylcholine from different sources, including other immune cells and the vagus nerve, and their activation causes suppression of pro-inflammatory cytokines. Nicotine is able to suppress the production of pro-inflammatory cytokines by mimicking the binding of acetylcholine.
In the absence of any effective treatment for COVID-19, further research as to whether nicotine replacement offers protection against severe SAR-CoV-2 infection in smokers is clearly essential. If the mechanisms through which nicotine may interact with the virus remain speculative, the effects of route of administration, duration, dosing and frequency of use of nicotine on any such interaction are unknown.
“It is the opinion of this research team and inventor that the menthol crystal fume attaches to the mucous membrane of the upper respiratory tract in the form of micro spikes or cilia (pseudo-cilia). It is this pseudo-cilia, or spikes, that prevent the binding of the S protein of the COVID-19 virus to the ACE-2 receptors on the human cells, thus preventing a successful invasion into the body by the virus,” said Christopher Ogunsalu.
Christopher Ogunsalu
DENTIST, MEDICAL DOCTOR, MAXILLOFACIAL SURGEON & RADIOLOGIST
Ibadan University
BACKGROUND checks on controversial dentist, Nigerian-born Dr Christopher Ogunsalu have revealed that he was charged in 2007 with assaulting a female assistant during a dispute at his Montego Bay office in St James.
The dental specialist triggered a firestorm recently by requesting $1.8 million for the release of his findings from an analysis of remains believed to be those of murdered Trinidadian school teacher Michelle Coudray-Greaves before producing the report to the Montego Bay Resident Magistrate's Court on Friday morning.
At the same time, Coudray-Greaves' mother has expressed disappointment at Ogunsalu's action, which had stalled the murder case and caused much pain to loved ones.
But can the finding be used, and how? Daniel Ogunsalu, a UWI, Mona, undergraduate student, has developed methods by which menthol crystal can be used to prevention COVID-19, including a self-assembled device to replace the face mask comprising a face shield attached to eyeglasses with a slot for a menthol pack. This slot will carry a replaceable perforated cassette (plastic or paper). Larger cassettes have also been devised to be used in houses, offices, and inside motor vehicles. Alternatively, he said, the shield could be mentholated overnight in a container.
. . . The team has decided not to patent its discovery so it can be immediately engaged in the global fight against COVID-19, especially with many developing countries being left behind in the vaccination race.
Christopher Ogunsalu
DENTIST, MEDICAL DOCTOR, MAXILLOFACIAL SURGEON & RADIOLOGIST
Ibadan University
Thursday’s announcement is the result of a lawsuit filed by anti-smoking and medical groups last summer to force the FDA to finally make a decision on menthol, alleging that regulators had “unreasonably delayed” responding to a 2013 petition seeking to ban the flavor.
The Food and Drug Administration has attempted several times to get rid of menthol but faced pushback from Big Tobacco, members of Congress and competing political interests in both the Obama and Trump administrations. Any menthol ban will take years to implement and will likely face legal challenges from tobacco companies.
There are calcium channels in cell membranes throughout our bodies, and that is why we can see systemic toxicity after swallowing or inhaling concentrated amounts of menthol. Serious effects include seizures, coma, and death.
Menthol can cause eye and skin irritation.
Some nasal inhalers contain menthol. The menthol makes us feel as though we are breathing easier, but it does not actually help with congestion. In fact, it appears that more inflammation develops.
Menthol Enhances the Desensitization of Human α3β4 Nicotinic Acetylcholine Receptors
Abstract - The α3β4 nicotinic acetylcholine receptor (nAChR) subtype is widely expressed in the peripheral and central nervous systems, including in airway sensory nerves. The nAChR subtype transduces the irritant effects of nicotine in tobacco smoke and, in certain brain areas, may be involved in nicotine addiction and/or withdrawal. Menthol, a widely used additive in cigarettes, is a potential analgesic and/or counterirritant at sensory nerves and may also influence nicotine’s actions in the brain.
Nicotine is an agonist (attaches) at the α7 subunit of nicotinic acetylcholine (α7-nACh) receptors on innate immune cells such as macrophages.
originally posted by: angelchemuel
Menthol is highly toxic and can even be fatal with overuse. Using it in it's crystal form like this is highly dangerous in my view.
There are calcium channels in cell membranes throughout our bodies, and that is why we can see systemic toxicity after swallowing or inhaling concentrated amounts of menthol. Serious effects include seizures, coma, and death.
Menthol can cause eye and skin irritation.
Some nasal inhalers contain menthol. The menthol makes us feel as though we are breathing easier, but it does not actually help with congestion. In fact, it appears that more inflammation develops.
Menthol
Menthol cigarettes have been banned in UK since May 2020....a year ago.
Rainbows
Jane
originally posted by: MichiganSwampBuck
The toxicity of menthol is a good point, one I should have looked into. Add that to frogs453 post about the 2013 petition to ban menthol in cigarettes, and my paranoid conspiracy theory begins to dissolve.
However, nicotine is still on the table. There is always that to cling to on my sinking ship.