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Mounting evidence of fleeting immune response
In the first known estimation of the rate of SARS-CoV-2 antibody decay, the researchers studied the blood samples of 20 women and 14 men who had recovered from a mild case of COVID-19. They conducted tests to detect and quantify immunoglobulin G (IgG) antibodies against the coronavirus 36 and 82 days, on average, after symptom onset in 31 participants. The remaining three were tested three times between roughly 37 to 86 days after illness onset.
Mean participant age was 43 years (range, 21 to 68). Four of the 34 participants had symptoms characteristic of COVID-19 and an infected household contact but not been tested because of only mild illness and limited testing availability.
The protective role of antibodies against the novel coronavirus is not known, but antibodies usually confer at least partial antiviral immunity for some time, the authors noted. The study found that the rate of antibody loss for SARS-CoV-2 was faster than that reported for SARS-CoV-1, the virus that causes severe acute respiratory syndrome (SARS).
The findings are similar to those of several previous reports showing rapidly decreasing antibody levels after infection, including one published Jun 18 in Nature, which showed that levels of antibodies against COVID-19 began to decrease within 2 or 3 months of infection.
“The antibodies decline, but they settle in what looks like a stable nadir,” which is observable about three months after symptoms start, Dr. Bhattacharya said. “The response looks perfectly durable.”Seeing antibodies this long after infection is a strong indication that B cells are still chugging away in the bone marrow, Dr. Pepper said. She and her team were also able to pluck B cells that recognize the coronavirus from the blood of people who have recovered from mild cases of Covid-19 and grow them in the lab.
Multiple studies, including one published on Friday in the journal Cell, have also managed to isolate coronavirus-attacking T cells from the blood of recovered individuals — long after symptoms have disappeared. When provoked with bits of the coronavirus in the lab, these T cells pumped out virus-fighting signals, and cloned themselves into fresh armies ready to confront a familiar foe. Some reports have noted that analyses of T cells could give researchers a glimpse into the immune response to the coronavirus, even in patients whose antibody levels have declined to a point where they are difficult to detect.
“This is very promising,” said Smita Iyer, an immunologist at the University of California, Davis, who is studying immune responses to the coronavirus in rhesus macaques but was not involved in the new studies. “This calls for some optimism about herd immunity, and potentially a vaccine.”
The study found that, despite the high impact of COVID-19 in Spain, estimates of the prevalence of antibodies remain low and are “clearly insufficient” to provide herd immunity. “This cannot be achieved without accepting the collateral damage of many deaths in the susceptible population and overburdening of health systems,” the researchers wrote. “In this situation, social distance measures and efforts to identify and isolate new cases and their contacts are imperative for future epidemic control.”
originally posted by: chr0naut
a reply to: Fallingdown
This isn't new because you only just found out about it!
It is already the predominant strain in the USA and was identified back in February.
Look at all the other countries that had a major problem with COVID-19, and have now gotten over it. Just about every other country except for the UK and the USA.
What is wrong with those countries who haven't brought it under control and that have then suggested that this is somehow political? Sounds like they are incapable of doing what even third world, un-technological, poor countries have done.
Yes. A whole lot more people.
Basically they are saying more people will die getting to herd immunity...and while that may be true more people will die either way be it by broken economies or the virus.
Why do you think that?
I still think allowing doctors to use the HCQ Z-pack Zinc treatmemt will cut a lot of that way down.
Yes, health care folks are learning.
Less people are dying now
There is nothing preventing doctors from trying. The problem is that claims that it is a "cure" do not help the situation. Such claims minimize the threat and that is counterproductive.
...why not try.
originally posted by: putnam6
originally posted by: chr0naut
a reply to: Fallingdown
This isn't new because you only just found out about it!
It is already the predominant strain in the USA and was identified back in February.
Look at all the other countries that had a major problem with COVID-19, and have now gotten over it. Just about every other country except for the UK and the USA.
What is wrong with those countries who haven't brought it under control and that have then suggested that this is somehow political? Sounds like they are incapable of doing what even third world, un-technological, poor countries have done.
www.worldometers.info...
The US is 10th in deaths per million the only semi fair way to judge these countries like Belgium Peru the UK Spain Italy and Sweden
according to covid19-r0.com...
The US Rt from Covid-19 Rt World Statistics the US is at 1.1 while plenty of European countries are higher like Germany is at 1.5 even Canada is at 1.3
but lets not let facts get in the way, remember Italy ravaged early shutdown early still has more deaths per million and a higher transmission rate 1.3 and the UK has more than Italy
How do they know it helps? Do they have a control group?
Because every doctor I have read about who is using it has been saying it helps a lot and has cut way back on hospitalizations and deaths.
I have heard of such an instance. But I don't think it's what you're talking about.
Many pharmacies in the US refuse to give HCQ even if prescribed it
www.foxnews.com...
A 42-year-old woman from the Los Angeles area who’s diagnosed with lupus said her health care provider stopped filling her prescription for chloroquine – and sent her a message thanking her for her “sacrifice” to help treat those seriously ill with the coronavirus.
originally posted by: KnoxMSP
a reply to: chr0naut
Most other countries, like yours, pale in comparison to the size and population of the US. Pretty easy to figure out.