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originally posted by: tgidkp
a reply to: ketsuko
wow! that is incredible!!
your husband's conclusion if the EXACT OPPOSITE of what the paper actually says!
what, exactly, are your husband's credentials? because the paper actually says the opposite of what he has concluded.
... just, wow.
originally posted by: TheAMEDDDoc
a reply to: Bicent
Herpes viruses are weirdos, your monos, chicken pox, simplex, cmvs. They linger and like to travel along nerves. They can become active when our immune system is weakened.
We get infected, reinfected with coronavirus every year, usually we’re immune or partially immune, if not we get a cold. We should be able to eliminate it from our systems but there have been reports of coronavirus going latent to evade the immune system or when it crosses the blood brain barrier.
SARS was found everywhere in the body in systemic patients that died. Respiratory viruses usually don’t go latent because of the tissue it infects and how it must fight innate and adaptive immune responses.
HIV is another oddball that only really targets cells with a specific receptor called CD4. Its found in many immune cells and is only really contagious when it infects certain cells like dendritic cells that are closer to the external environment. It goes latent when it shifts to T helper cells which are critical for identifying pathogens. You’re only at risk of infection with deep tissue injury of contaminated objects.
originally posted by: ketsuko
a reply to: Advantage
People who carry residual antibodies from this go around may have some resistance to it though because it will still be somewhat close to what it was. And those who had it will have less of a hyper aggressive immune response because a good chunk of the virus will be similar to what it was.
Antigenic drift is a kind of genetic variation in viruses, arising by the accumulation of mutations in the virus genes that code for virus-surface proteins that host antibodies recognize. This results in a new strain of virus particles that is not effectively inhibited by the antibodies that prevented infection by previous strains. This makes it easier for the changed virus to spread throughout a partially immune population. Antigenic drift occurs in both influenza A and influenza B viruses.
(Confusion can arise with two very similar terms, antigenic shift and genetic drift. Antigenic shift is a closely related process; it refers to more dramatic changes in the virus's surface proteins. Genetic drift is very different and much more broadly applicable; it refers to the gradual accumulation in any DNA sequence of random mutational changes that do not interfere with the DNA's function and thus that are not seen by natural selection.)
The immune system recognizes viruses when antigens on the surfaces of virus particles bind to immune receptors that are specific for these antigens. These receptors can be antibodies in the bloodstream or similar proteins on the surfaces of immune-system cells. This recognition is quite precise, like a lock recognizing a key. After an infection or after vaccination, the body produces many more of these virus-specific immune receptors, which prevent re-infection by this particular strain of the virus; this is called acquired immunity. However, viral genomes are constantly mutating, producing new forms of these antigens. If one of these new forms of an antigen is sufficiently different from the old antigen, it will no longer bind to the antibodies or immune-cell receptors, allowing the mutant virus to infect people who were immune to the original strain of the virus because of prior infection or vaccination.