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Tumor cells that spread cancer via the bloodstream face a new foe: a laser beam, shined from outside the skin, that finds and kills these metastatic little demons on the spot.
In a study published today in Science Translational Medicine, researchers revealed that their system accurately detected these cells in 27 out of 28 people with cancer, with a sensitivity that is about 1,000 times better than current technology. That’s an achievement in itself, but the research team was also able to kill a high percentage of the cancer-spreading cells, in real time, as they raced through the veins of the participants.
Abstract
Most cancer deaths arise from metastases as a result of circulating tumor cells (CTCs) spreading from the primary tumor to vital organs. Despite progress in cancer prognosis, the role of CTCs in early disease diagnosis is unclear because of the low sensitivity of CTC assays. We demonstrate the high sensitivity of the Cytophone technology using an in vivo photoacoustic flow cytometry platform with a high pulse rate laser and focused ultrasound transducers for label-free detection of melanin-bearing CTCs in patients with melanoma. The transcutaneous delivery of laser pulses via intact skin to a blood vessel results in the generation of acoustic waves from CTCs, which are amplified by vapor nanobubbles around intrinsic melanin nanoclusters. The time-resolved detection of acoustic waves using fast signal processing algorithms makes photoacoustic data tolerant to skin pigmentation and motion. No CTC-associated signals within established thresholds were identified in 19 healthy volunteers, but 27 of 28 patients with melanoma displayed signals consistent with single, clustered, and likely rolling CTCs. The detection limit ranged down to 1 CTC/liter of blood, which is ~1000 times better than in preexisting assays. The Cytophone could detect individual CTCs at a concentration of ≥1 CTC/ml in 20 s and could also identify clots and CTC-clot emboli. The in vivo results were verified with six ex vivo methods. These data suggest the potential of in vivo blood testing with the Cytophone for early melanoma screening, assessment of disease recurrence, and monitoring of the physical destruction of CTCs through real-time CTC counting.
originally posted by: projectvxn
a reply to: bobs_uruncle
532nm may not be what makes it special. It's just a green laser.
There is certainly more to this than the wavelength of the laser.
originally posted by: projectvxn
a reply to: bobs_uruncle
532nm may not be what makes it special. It's just a green laser.
There is certainly more to this than the wavelength of the laser.
originally posted by: one4all
Uncle_Bob...critical mass.....MMMmmmmm…..what unique property of a pleomorphic bacteria can be targeted and pushed over the rubicon of its critical mass spectrum using the tools used in the experiment.
originally posted by: bobs_uruncle
originally posted by: one4all
Uncle_Bob...critical mass.....MMMmmmmm…..what unique property of a pleomorphic bacteria can be targeted and pushed over the rubicon of its critical mass spectrum using the tools used in the experiment.
I have only done cellular and cluster emf signature analysis for the NRC. I actually hold a patent in that area. It seems that destructive interference can create a situation where the microtubule tendrils of diseased cells are incapable of communication. This renders the cancer "organism" impotent and incapable of symbiotic proliferation. It is of course possible that 532nm has an effect on a cancer-cell-in-transit's ability to anchor itself to other cells, thereby cutting off its food supply resulting in localized cachexia killing the cell or making it incapable of functioning.
Eta: I don't know if they have looked at it, but cancers could actually also be a food allergy response. There are many allergic reactions that take days to propogate. Uvietis is a modification of protein p258 in the eyes. Subcutaneous t-cell lymphoma and pityriasis rubra Polaris both trigger protein p53 in the skin causing a form of cachexia in the 1st-3rd dermal layers. So the expression of cancer can also appear to be autoimmune system triggered. This would fall in line with chemicals that are known to cause cancer like methylene chloride, glyphosate, tetrachloroethylene, carbon tetrachloride, etc. as these chemicals are known to cause genetic mutations at the cellular/DNA level.
Cheers - Dave