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originally posted by: TzarChasm
a reply to: cooperton
Multiple consecutive generations of altered gene expression = man made evolution
Conclusion In this report we describe the evolution of antibiotic resistance in bacteria mediated by the epigenetic inheritance of variant gene expression patterns. This provides proof in principle that epigenetic inheritance, as well as DNA mutation, can drive evolution.
The analysis of regulation of the EcoRV, CfrBI and LlaJI R-M systems described above has provided insight into the evolution of epigenetic control systems that are predominantly controlled by “orphan” methyltransferases, including DNA cytosine methylase (Dcm) (202) in E. coli.
Dam homologues without a restriction enzyme counterpart are also present in bacteriophages, including Sulfolobus neozealandicus droplet-shaped virus (7), halophilic phage φCh1 (15), H. influenzae phage HP1 (204), phage P1 (61), phage T1 (9), and phage T4 (226). The last MTase, T4Dam, has been well characterized biochemically, primarily by Hattman and colleagues (123, 228). T4Dam, like EcoDam, is highly processive (169) and complements a dam mutant E. coli mutator phenotype (226). T4Dam and EcoDam may have a common evolutionary origin, sharing up to 64% sequence identity in four different regions (11 to 33 amino acids long) (105).
All pap Lrp binding sites share the sequence “GNNNTTT” with the Lrp binding consensus determined by systematic evolution of ligands by exponential enrichment (64).
Cutting phage genomes in a precise manner may optimize DNA packaging and facilitate circularization of phage DNA upon entry into the next recipient cell. However, the use of Dam methylation to label phage DNA ends is an enigmatic evolutionary acquisition.
The fact that two independent bacterial lineages (Gammaproteobacteria and Alphaproteobacteria) use DNA adenine methylation as a signal for the initiation of chromosome replication is an interesting case of evolutionary convergence, which is strengthened by the evidence that the DNA methylases involved (Dam or CcrM) are also of independent origin.
Two of these enzymes, the Dam methylase of enteric bacteria and the CcrM methylase of Caulobacter crescentus, are paradigms of an evolutionary process in which DNA adenine methylation acts as a signaling mechanism that regulates DNA-protein interactions.
) Fig. 4 reports the evolutionof the RI for different populations subjected to a different number M of antibiotic shocks. In each case, the arrows indicate the time at which the antibiotic is removed. The results depicted in Fig. 4 show that the final stationary value of the resistance index (the one reached when the antibiotic is removed) depends on how long the population remains in contact with the antibiotic
It is important to mention that the increase in the basal level of the RI shown in Fig. 4A when the population is kept in a high antibiotic concentration for a long time is non reversible. Indeed, Fig. 4D shows the evolutionacross generations of the average pump efficiency με and the average transcription rate μβ for the population corresponding to the blue curve of Fig. 4A.
In this study we present a theoretical framework that identifies the essential mechanisms for the emergence,evolution and reversibility of adaptive resistance.
The results presented in Fig. 4 indicate that the permanent change in the RI observed after a long induction time is not due to transitions between fixed points, but to the fact that the unique fixed point of each cell moves throughout the evolutionof the population.
Evolutionary theory insists that all organisms resulted from ancestral organisms that underwent gradual changes throughout generations. If this is true we should be able to emulate this transition in a lab, but we have not, despite trying with, for example, millions of generations of fruit flies over many labs throughout the world.
originally posted by: cooperton
originally posted by: Barcs
We are referring to research to make the case for evolution, not opinion. Experiments and tests.
Ok good the rubber meeting the road. So what experiment, the empirical evidence, not just appeals to authority opinion, demonstrates the validity of evolution. One at a time and we can dissect each one.
originally posted by: Observationalist
a reply to: Phantom423
The results of Evolution we observe in nature today didn’t happen in a lab. It is said to have occurred in the Uniformitarians type landscape. How does showing in a lab prove anything other than it’s very deliberate and guided process to get an organism to show a succession of adaptations.
That’s like praying for the Browns(worst Football team ever) to win the Super Bowl. But the only way they can win is if your play a virtual super bowl in a video game. God answered your prayers right? They won.
If evolution is such a slam dunk then we should see a bottomless pit of the losers bones and fossils in the rock layers. Hell based on some of the research evolution does not stop so why can’t we observe it now. Oh that’s right it takes 3.23 zillion years.
Anyway, I think we should be able to go for a walk in the tall grass and you should be able to show me a grasshopper evolving into anything other than a bigger grasshopper.
Anyway, I think we should be able to go for a walk in the tall grass and you should be able to show me a grasshopper evolving into anything other than a bigger grasshopper.
Another much more serious problem, however, is posed by forged, faked and manipulated specimens – such as National Geographic’s Archaeoraptor – which are becoming increasingly common. Farmers who dig for fossils do so to supplement their meagre incomes and are well aware that complete and spectacular specimens are worth far more than the fragmentary remains. Some don’t even realize they are faking specimens and combine pieces of different fossils found at the same locale. In the most extreme cases, this manipulation is intentional, involving fossils found at disparate locations. It sounds crude, but even the experts have to look carefully to detect the trickery when master forgers have been at work.
It’s a significant hurdle to good science, and one that can’t easily be solved. ‘Fossil forgery in the last decade highlights some troubling trends in Chinese vertebrate paleontology’, wrote Xiaoming Wang, a paleontologist at the Natural History Museum of Los Angeles County in an opinion piece for the journal PNAS. “While fossil forgeries unfailingly stoke public fascination … the widespread damages that forgery causes are often not sufficiently recognized.
It turns out that today's dog breeds may not have evolved from the gray wolf, at least not the kind of gray wolf that exists today. A study in the current issue of PLoS Genetics suggests that, instead, dogs and gray wolves share a common ancestor in an extinct wolf lineage that lived thousands of years ago. An international team of researchers generated genome sequences from three gray wolves – one each from China, Croatia, and Israel, the three countries where dogs are believed to have originated. They then sequenced the genome of a basenji dog from central Africa and a dingo from Australia. Both the regions have been historically isolated from wolf populations, according to a press release by The University of Chicago Medical Center.
It turns out that today's dog breeds may not have evolved from the gray wolf, at least not the kind of gray wolf that exists today. A study in the current issue of PLoS Genetics suggests that, instead, dogs and gray wolves share a common ancestor in an extinct wolf lineage that lived thousands of years ago. An international team of researchers generated genome sequences from three gray wolves – one each from China, Croatia, and Israel, the three countries where dogs are believed to have originated. They then sequenced the genome of a basenji dog from central Africa and a dingo from Australia. Both the regions have been historically isolated from wolf populations, according to a press release by The University of Chicago Medical Center.
a group of living organisms consisting of similar individuals capable of exchanging genes or interbreeding. The species is the principal natural taxonomic unit, ranking below a genus and denoted by a Latin binomial, e.g. Homo sapiens.
We have all of these famous stories in our history that pit science against faith – Galileo’s trial before the Inquisition, the Anglican Church’s strong public condemnation of Charles Darwin and the debates that followed the publication of his On the Origin of Species, the Scopes trial. And they have created this impression that there is an inherent conflict between religion and science. Do you believe there is such an inherent conflict? And if there isn’t, why is this impression false?
I don’t believe there is an inherent conflict, but I believe that humans, in our imperfect nature, sometimes imagine conflicts where there are none. We see something that threatens our own personal view, and we figure that there must be some reason why that alternative view has to be wrong, or even why it has to be evil.
First of all, let’s look carefully at the history of conflicts between science and the church and be sure that those are adequately represented. The story of Galileo is an interesting one. But I think it might be fair to say that Galileo’s greatest mistake was being a bit arrogant in the way he presented his own views and insulting the pope who, prior to that, had been fairly sympathetic with Galileo’s conclusions. Basically the pope couldn’t let Galileo get away with this kind of insult. Similarly, I think when Onthe Origin of Species was published, while there were objections coming from the church, there was also a large segment of the church, including some conservative theologians like Presbyterian Minister Benjamin Warfield, who embraced this new view of how living things were related to each other as a wonderful insight into the method by which God must have carried out creation.
Perhaps today’s conflict, which seems particularly intense, is so difficult to understand because, after all, evolution has been very much on the scene for 150 years, and the science that supports Darwin’s theory has gotten stronger and stronger over those decades. That evidence is particularly strong today given the ability to study DNA and to see the way in which it undergirds Darwin’s theory in a marvelously digital fashion. And yet, we have seen an increasing polarization between the scientific and spiritual worldviews, much of it, I think, driven by those who are threatened by the alternatives and who are unwilling to consider the possibility that there might be harmony here.