Scientists Genetically Modify Virus To Kill Cancer Cells

Finally, a virus to kill cancer (wait, didn't I see this in a Will Smith movie?). This time they have managed to engineer a virus that will kill the cancer and associated fibroblasts without hurting the rest of the body.

Now, will we ever see this cure available or is this the last we will ever hear about it?

www.eurekalert.org...

In this study, published in the journal Cancer Research, the researchers used a virus called enadenotucirev, which is already in clinical trials for treating carcinomas. It has been bred to infect only cancer cells, leaving healthy cells alone.

They added genetic instructions into the virus that caused infected cancer cells to produce a protein called a bispecific T-cell engager.

The protein was designed to bind to two types of cells and stick them together. In this case, one end was targeted to bind to fibroblasts. The other end specifically stuck to T cells - a type of immune cell that is responsible for killing defective cells. This triggered the T cells to kill the attached fibroblasts.

Dr Joshua Freedman, from the Department of Oncology at the University of Oxford, who was first author on the study said: "We hijacked the virus's machinery so the T-cell engager would be made only in infected cancer cells and nowhere else in the body. The T-cell engager molecule is so powerful that it can activate immune cells inside the tumour, which are being supressed by the cancer, to attack the fibroblasts."

Dr Kerry Fisher, from the Department of Oncology at the University of Oxford, who led the research said: "Even when most of the cancer cells in a carcinoma are killed, fibroblasts can protect the residual cancer cells and help them to recover and flourish. Until now, there has not been any way to kill both cancer cells and the fibroblasts protecting them at the same time, without harming the rest of the body.

"Our new technique to simultaneously target the fibroblasts while killing cancer cells with the virus could be an important step towards reducing immune system suppression within carcinomas and should kick-start the normal immune process.

nypost.com...

A genetically modified virus that kills cancer cells and destroys their hiding places has been developed by British scientists.

The virus, developed by Oxford University scientists, attacks carcinomas, which are the most ­common type of cancer. The findings were published in Cancer Research.

So researchers used a virus called enadenotucirev, which is already in clinical trials for treating carcinomas.

It has been bred to infect only cancer cells, leaving healthy cells alone.

“Until now, there has not been any way to kill both cancer cells and the fibroblasts protecting them at the same time, without harming the rest of the body.”

“Our new technique to simultaneously target the fibroblasts while killing cancer cells with the virus could be an important step towards reducing immune system suppression within carcinomas and should kick-start the normal immune process.”

An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
cancerres.aacrjournals.org...

Sounds like they found a way to genetically engineer the common cold virus so they could patent it. The common cold kills cancer cells, so do some other viruses.

a reply to: rickymouse

Links please? I'm intrigued.

a reply to: infolurker

They've been doing studies in this realm for some time.

Problem with cancer is it's our own cells gone rogue, our immune system doesn't target them.

They were taking cancer cells from humans, putting them in mice and stealing the T cells from the mice and putting that in the patient. Sometimes the T cells would attack before their immune system neutralized them.

Question is, do they want to cure cancer?

a reply to: rickymouse

cancerres.aacrjournals.org...

Significance: An engineered oncolytic adenovirus that encodes a bispecific antibody combines direct virolysis with endogenous T-cell activation to attack stromal fibroblasts, providing a multimodal treatment strategy within a single therapeutic agent. Cancer Res; 1–14. ©2018 AACR.

Cancer is a pleomorphic bacteria....it is a bacteria that can morph to present in a viral form....so they plicks built hunter-killer viruses to kill this stage of a pleomorphic bacterias life...instead of just killing it sooner in an earlier stage....this is so they can cure specific cancers and not all of them...all we have to do it treat the foods we eat that give us the parasites that carry the bacteria that morph into what we call cancer in their fungal stages when forced there..what we call cancer is a fungal presentation of a pleomorphic bacteria that is in danger of death and has triggered its survival instinct to reproduce prodigiously before it perishes... this bacteria has to be PUSHED to this point...it can be killed at the parasitic connection point...before we ingest it where it remains dormant in nearly all of us....till we as per TPTBs plans ingest the foods and chemicals that support said bacteria and its stages or that mediate the body into a sympathetic state to trigger the bacterias morphing forms to adapt and survive.

a reply to: one4all

it can be killed at the parasitic connection point

curious how, before eating or after?

originally posted by: Wide-Eyes
a reply to: rickymouse

Links please? I'm intrigued.

www.insidescience.org...

trialx.com...

www.sciencedaily.com...

Cancer cells are fast replicating and they eat a lot, so the viruses are attracted to the cancer cells. You can also consume foods like parsley and celery and the hungry cancer cells gorge on the chemicals these plants contain that cause aptopsis and they die. That is the basis of one of the most recent cancer meds, you know, the one that is the highest price of all, patented celery flakes.

How about a combo of a cold and the parsley family chemistry contained within chicken soup. Double whammy against cancer. Also rutabaga has some strong anticancer properties.

originally posted by: rickymouse

originally posted by: Wide-Eyes
a reply to: rickymouse

Links please? I'm intrigued.

www.insidescience.org...

trialx.com...

www.sciencedaily.com...

Cancer cells are fast replicating and they eat a lot, so the viruses are attracted to the cancer cells. You can also consume foods like parsley and celery and the hungry cancer cells gorge on the chemicals these plants contain that cause aptopsis and they die. That is the basis of one of the most recent cancer meds, you know, the one that is the highest price of all, patented celery flakes.

How about a combo of a cold and the parsley family chemistry contained within chicken soup. Double whammy against cancer. Also rutabaga has some strong anticancer properties.

Also look up fasting and cancer, some very interesting stuff.

a reply to: rickymouse

Interesting... those articles are from 2012... whatever happened to using them?

a reply to: infolurker

Sounds like the Krippen Virus.

Once in a while, I read about a cure for cancer but never read when it will be available and how much it will cost.

originally posted by: JAGStorm
a reply to: one4all

it can be killed at the parasitic connection point

curious how, before eating or after?

Food can be treated for parasitic catalysts along with unique things like trojan horse sugar molecules like the one in pigs blood vessels... before we eat it.We can treat ourselves if we have the dormant bacteria in our bodies.

This will be the end of us all. Something is bound to go wrong somewhere, and it will probably evolve into a flesh-morphing horror. We'll all be Cronenberged into an early grave.

There isn't any money in curing diseases only in treating the symptoms. I doubt anything will come of this because no way Big Pharma would allow this to wipe out their cash cow.

a reply to: one4all

Cancer isnt a bacteria. If it was the body would treat it as such, and a massive dose of antibiotics would treat early stages of cancer.

a reply to: infolurker

Great, they've found another cure. That's Step 1.

Step 2: Find a way to make it into a treatment with lots of side effects.

Step 3: If Step 2 doesn't work, incriminate/kill anyone in the know and bury the discovery.

Step 4: Repeat

originally posted by: strongfp
a reply to: one4all

Cancer isnt a bacteria. If it was the body would treat it as such, and a massive dose of antibiotics would treat early stages of cancer.

Its a bacteria that is pleomorphic and it adapts and adjusts.

originally posted by: one4all

originally posted by: strongfp
a reply to: one4all

Cancer isnt a bacteria. If it was the body would treat it as such, and a massive dose of antibiotics would treat early stages of cancer.

Its a bacteria that is pleomorphic and it adapts and adjusts.

So, why can't cancer be killed by antibiotics?

Pleomorphia doesn't grant any special overt antibiotic resistance in any study I've seen.

originally posted by: rickymouse
Sounds like they found a way to genetically engineer the common cold virus so they could patent it. The common cold kills cancer cells, so do some other viruses.

Source please? You can't just say something so fantastic and not back it up. Please?