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originally posted by: FauxMulder
This technology hasn't been applied to humans yet. It has only been tested with mice.
originally posted by: GuidedKill
Could we use this on a grand scale and turn these protestors/rioters/ANTIFA/KKK/BLM etc. into a giant human centipede???
That's something I can get behind!!!
Eeeuuwwwww!!!
I'm no protester but if I get stuck in one of those things I'd rather be at the front!!
originally posted by: 3NL1GHT3N3D1
This is kinda scary. Imagine being the assassination patsy or terrorist attack patsy being aware of what you're doing but not being able to stop it.
Crazy times we live in.
originally posted by: AMPTAH
originally posted by: FauxMulder
This technology hasn't been applied to humans yet. It has only been tested with mice.
Maybe that professor's particular work has only been tested with mice.
I can assure you that humans have already been hacked, and have had their arms and legs controlled without their will.
No DNA implant threads required.
originally posted by: UnderKingsPeak
i suspect there are already means
to jumble a brain with microwaves.
This was an epidemic a few years ago
as I believe field testing began
Great way to ruin anyone.
Scientist Remotely Hack Brain. Control Body.
originally posted by: 3NL1GHT3N3D1
This is kinda scary. Imagine being the assassination patsy or terrorist attack patsy being aware of what you're doing but not being able to stop it.
Crazy times we live in.
Brain implantation and manipulation is a mainstay of science fiction. Often, characters can gain extra memory or get smarter, by having chips placed within the brain. (Or you can wind up mind-controlled by a psychopath. It's a mixed bag.)
But in real life, one scientist made huge strides towards creating workable brain implants. In the 1950s and 1960s. Here's his story.
Jose Delgado performed experiments using permanent brain implants in bulls, primates, and humans beginning in the 1950s, with extremely successful results. Neuroscience often ignores this chapter of its history, but it's worth taking a look at Delgado's successes, and his long term goals for manipulation of humans and society.
A Scientist plays Matador
Delgado became a matador to demonstrate the abilities of stimoceiver manipulation, as he stepped into a closed ring with an implanted bull armed only with a radio frequency controller in 1963. When the bull charged, Delgado stimulated the bull's motor cortex with the remote control, causing the bull to come to a full stop only feet away.
In a 1965 New York Times interview about the matador experiment, Delgado foreshadowed the future of human experimentation:
The individual may think that the most important reality is his own existence, but this is only his personal point of view. This lacks historical perspective. Man does not have the right to develop his own mind. This kind of liberal orientation has great appeal. We must electronically control the brain. Someday armies and generals will be controlled by electric stimulation of the brain.
While we don’t have a unified field theory of the brain, some of the early projects in the BRAIN Initiative are providing models of how behavior emerges from brain activity. One of the first grants issued by the BRAIN Initiative supported scientists at NIMH and the University of Maryland to understand how the activity of individual neurons is integrated into larger patterns of brain activity. This work builds on the observation that in nature, order sometimes emerges out of the chaos of individual interacting elements.2
originally posted by: Sapphire
a reply to: FauxMulder
Scientist Remotely Hack Brain. Control Body.
This would explain what the hell is wrong with the world, and whoever the heads are running this rock.
originally posted by: GuidedKill
Could we use this on a grand scale and turn these protestors/rioters/ANTIFA/KKK/BLM etc. into a giant human centipede???
That's something I can get behind!!!
Imagine someone remotely controlling your brain, forcing your body’s central processing organ to send messages to your muscles that you didn’t authorize. It’s an incredibly scary thought, but scientists have managed to accomplish this science fiction nightmare for real, albeit on a much small scale, and they were even able to prompt their test subject to run, freeze in place, or even completely lose control over their limbs. Thankfully, the research will be used for good rather than evil… for now.
The effort, led by physics professor Arnd Pralle, PhD, of the University at Buffalo College of Arts and Sciences, focused on a technique called “magneto-thermal stimulation.” It’s not exactly a simple process — it requires the implantation of specially built DNA strands and nanoparticles which attach to specific neurons — but once the minimally invasive procedure is over, the brain can be remotely controlled via an alternating magnetic field. When those magnetic inputs are applied, the particles heat up, causing the neurons to fire.
The study, which was published in the most recent edition of the journal eLife, includes experiments where were performed on mice. Using the new technique, the researchers were able to control the movement of the animals, causing them to freeze, lock up their limbs, turn around, or even run.
Effort to Remotely Control Brain Cells Gets Push from Innovative Grant
Scientists developing a non-invasive technique for triggering brain activity receive $1.2 million from the Human Frontier Science Program .
The project is led by University at Buffalo Assistant Professor Arnd Pralle, PhD, a physicist who has pioneered a method of using tiny, magnetic particles to remotely induce neurons to fire.
The Human Frontier Science Program is a program of funding for frontier research in the life sciences. It is implemented by the International Human Frontier Science Program Organization (HFSPO) with its office in Strasbourg.
Members
The members of the HFSPO, the so-called Management Supporting Parties (MSPs) are the contributing countries and the European Union, which contributes on behalf of the non-G7 EU members.
The current MSPs are Australia, Canada, France, Germany, India, Italy, Japan, Republic of Korea, Norway, New Zealand, Singapore, Switzerland the United Kingdom, the United States of America and the European Union.
Arnd Pralle, PhD
Associate Professor
136 Fronczak Hall
(716) 645-3069
Lab: 146 & 150 Fronczak Hall, (716) 645-2677
[email protected]
Website
Education
MS, Physics, Justus-Liebig-University (JLU), Giessen – 1994
PhD, Physics, EMBL, Heidelberg, and Ludwig-Maximilians-University (LMU), Munich – 1999
Postdoctoral Research at the Max-Plank-Inst. Mol. Cell Biology and Genetics, Dresden – 1999-2000; Human Frontier Science Program (HSFP) Fellow at University of California Berkeley, CA – 2001-2005
Specialties
Cellular Biophysics, Membrane Structure and Signaling, Advanced Microscopy and Spectroscopy, Magnetogenetics, Magnetothermal Stimulation, Nanoscale Heat Transport
My interests are the physics of cellular communication and morphology. We focus on two areas: the structure and dynamics of the cell surface in health and disease; and remote communication with neurons deep inside the brain. The cell surface is the communication gateway for cells, and its intrinsic structure is important for many processes, such as the immune response, cancer, organ development and cellular communication. External factors such as fever, adjuvants in vaccines, anesthetics, cholesterol changes throughout life, surface strain and mechanics affect the cell surface while the cell regulates it.We study why and how, under physiological conditions, cells spend energy to keep the structure in non-equilibrium conditions. For this, we use and develop ultra-resolution methods (camera based Fluorescence Correlation Spectroscopy (bimFCS), TIRF, Single Molecule, Optical Trapping) in combination with computer simulations of the system.
Molecular Temperature Measurements
Behavior and emotions are control of by signaling networks deep inside the brain. Our group has developed magnetogenetics, the magneto-thermal stimulation and silencing of specific neuronal circuits inside the brain of awake, moving animals. To achieves this, the neurons are temperature sensitized using an appropriate ion-channel and superparamagnetic nanoparticles are delivered to their cell surface. Then applying an alternating magnetic field heats those nanoparticles, causing the channels to activate or silence, respectively, the neurons. Using this method, we study brain circuitry, develop new silencing modalities, and investigate the temperature dependence of neuronal function. In addition, we study nanoscale heat-transport and magnetic nanoparticle heating.
The Pralle Lab at UB
Research
Our research interests lie at the interface of nanotechnology and cellular biophysics, and focus on the physics of signaling at the cell membrane. Some of us develop and investigate thermo-magnetic remote stimulation of proteins and cells using nanotechnology to study signaling networks. Others in our group investigate the cell membrane ultra-structure and how it modulates cell signaling for which we have developed two methods to image the nanoscale structure. Currently, we investigate how temperature, calcium concentration, protein-dimerization and cholesterol influence the ultrastructure, and how this structure modulates immune cell signaling.
Funding
NIH BRAIN award (R01MH111872, 2016-20) to develop magnetothermal genetic neurosilencing an apply with multiplexing to decision making in rats
NIH EUREKA award (R01MH094730, 2011-16) to apply magnetogenetics to mouse behavior
NIH R21 award (R21AI097879-01, 2012-14) to invesitgate the membrane biophysics of adjuvants mediated immunomodulation
Human Frontier Sciene Program award (HFSP RGP0052, 2012-16) to optimize thermomagnetic stimulation and to genetically encode it
MRI 0923133 to establish a confocal microscopy facility for pulsed-light imaging for FLIM and FCS between Biology and Physics
The head was shaved and rubbed with betadine and then ethanol. The skin was retracted and the periosteum was removed at the site. The scalp was opened and hole was drilled in the skull, through which a 33-gauge needle fitted in 5 µl syringe was inserted into the motor cortex (MC) or striatum1 (St1), or St2, left or right (See supplementary Table 1 for injection coordinates). Using that syringe and an automated syringe pump (World Precision Instruments), 600 nl virus were infused at a rate of 2 nl/s. The injection needle was raised 0.01 mm and kept in place for 5–10 min and slowly removed.