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Scientists attached an amine group to a compound called deoxynybomycin (DNM), which has the right flatness and rigidity. It’s also known to kill gram-positive bacteria. With the new functional group, the modified “6DNM-amine” was taken up by gram-negative cells and successfully killed them. They essentially converted DNM into a broad-spectrum antibiotic.
This could vastly increase the number of compounds that researchers consider for new drugs. The odds of finding something effective and safe for humans will be much higher if other teams can confirm these findings.