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Just a couple of weeks ago, researchers at the University of Virginia’s School of Medicine made a discovery which will forever alter the way we look at the brain, concluding that there is a direct connection between the brain and the immune system. This connection is by way of vessels that were previously assumed nonexistent.
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Jonathan Kipnis, a professor in the Department of Neuroscience and the Director of the University’s Center for Brain Immunology and Glia, expressed his surprise at the discovery: “I really did not believe there were structures in the body that we were not aware of. I thought the body was mapped.”
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According to Kipnis, questions like “How do we study the immune response of the brain?” or “Why do multiple sclerosis patients have immune system attacks?” no longer need to be answered thanks to this new discovery. “Now we can approach this mechanistically — because the brain is like every other tissue connected to the peripheral immune system through meningeal lymphatic vessels,” explained Kipnis. “We believe that for every neurological disease that has an immune component to it, these vessels may play a major role.”
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Behind the discovery was the work of Antoine Louveau, a postdoctoral fellow in Kipnis’ lab. He detected the vessels after developing a method that involved mounting a mouse’s meninges, which are the membranes covering the brain, onto a single slide in order to examine them in their entirety.
Loveau then detected vessel-like patterns in the distribution of immune cells on his slides, which caused him to test for lymphatic vessels, which he found. It seemed the impossible came to be.
The wise man of old said: "As a man thinketh in his heart so is he."
If you permit no thought of disease and death to enter your mind you will have accomplished nine-tenths of the battle to stave off these foes