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Monoamine Oxidase Inhibition Dramatically Increases the Motivation to Self-Administer Nicotine in Rats
We report that inhibition of MAO dramatically and specifically increases the motivation to self-administer nicotine in rats. These effects were more prominent in rats selected for high responsiveness to novelty than in rats with low responsiveness to novelty. The results suggest that the inhibition of MAO activity by compounds present in tobacco smoke may combine with nicotine to produce the intense reinforcing properties of cigarette smoking that lead to addiction.
Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type
The roll-your-own tobaccos tested delivered more tar and more MAO inhibitory activity per mg of nicotine than the factory-made cigarettes. These findings suggest that smokers of roll-your-own tobacco may experience greater difficulty in stopping smoking.
originally posted by: EA006
a reply to: cooperton
Good thread.
I'm currently trying to quit smoking, I've changed over to an e-cig.
Still bloody addictive though, like more use than the cigs I used to smoke.....
Any thoughts Op?
originally posted by: Astyanax
However, MAOs are not tobacco additives. They're actually in the tobacco, and commercially available loose-leaf tobacco contains more of them than does the tobacco in factory-made cigarettes.
Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type
Tobacco is a noxious, enslaving weed.
They were testing cigarette and pouch brands, not plain tobacco leaf. I've tried to find an experiment that involves just regular, unadulterated tobacco but I cannot find it. The Banisteriopsis vine used in the ayahuasca brew contains natural MAO-Inhibitors which is what prevents the '___' from getting metabolized, so I wouldn't rule it out as a possibility that tobacco could have natural MAO-I as well.
originally posted by: Mr Headshot
This is something I've said for a while. I use pipe tobacco, local bought. I enjoy it, I don't fiend or have real urges. It relaxes me, and tastes/smells nice. Oh, and no rat poison.
originally posted by: babybunnies
Bottom line is, yes, tobacco is bad for you.
Tobacco is also bad for the American worker. Did you know that the Tobacco industry is allowed to employ child laborers as young as 8 for up to 14 hours a day for about $50 a week.
Meanwhile, the average American is concerned about making sure the chickens that lay their eggs are free range, but no one discusses the CHILDREN who LEGALLY pick their tobacco, or the treatment of the average illegal immigrant who picks their vegetables, all in deplorable conditions that most people would be horrified about if they knew it was happening.
originally posted by: babybunnies
Bottom line is, yes, tobacco is bad for you.
Tobacco is also bad for the American worker. Did you know that the Tobacco industry is allowed to employ child laborers as young as 8 for up to 14 hours a day for about $50 a week.
Meanwhile, the average American is concerned about making sure the chickens that lay their eggs are free range, but no one discusses the CHILDREN who LEGALLY pick their tobacco, or the treatment of the average illegal immigrant who picks their vegetables, all in deplorable conditions that most people would be horrified about if they knew it was happening.
I've tried to find an experiment that involves just regular, unadulterated tobacco but I cannot find it... I wouldn't rule it out as a possibility that tobacco could have natural MAO-I as well.
Cigarette companies put MAO-Inhibitors in their cigarettes
Even nature's spirit cigarettes, which claim to have 100% additive free tobacco, still (this is speculation, because this information is well hidden) likely contains these addictive additives in the lacing of the cigarette. So they can legally say 100% additive free tobacco, yet still have chemicals in the lacing. Sneaky, sneaky, sneaky....
originally posted by: Astyanax
a reply to: cooperton
Cigarette companies put MAO-Inhibitors in their cigarettes
Were you making this statement up, or were you referring to the MAO inhibitors already present in tobacco?
Even nature's spirit cigarettes, which claim to have 100% additive free tobacco, still (this is speculation, because this information is well hidden) likely contains these addictive additives in the lacing of the cigarette. So they can legally say 100% additive free tobacco, yet still have chemicals in the lacing. Sneaky, sneaky, sneaky....
Astyanax: "Turns out your thread is based on a libellous speculation."
originally posted by: Pardon?
Smoking pretty much anything repetitively and over a long period of time will be bad for you.
End of.
There's no debate on that.
Just how bad "bad" is though, is subjective...especially when your head is in the sand...
Irrespective of the "toxins" inhaled the lungs will be irritated by the particulate matter in ANY smoke and that will inevitably lead to a reduction in lung capacity if repeated for long enough.
It's a studied and defined chronic process.
Source?
Me being a cardio-respiratory physiologist for several decades.
You are also jumping to conclusions if you think that article you gave me proves they are naturally occurring in the tobacco.
Look, I always appreciate your strong urge to challenge ideas that are presented. This is good, and I am in no way being sarcastic. But, the way you go about it has an unpleasant tone, you would be a much more effective interlocutor if you relaxed with the aggression.
originally posted by: Astyanax
a reply to: cooperton
You are also jumping to conclusions if you think that article you gave me proves they are naturally occurring in the tobacco.
You stated unequivocally that MAO inhibitors are deliberately added to cigarettes.
This is a libellous speculation -- until you show us proof that they are so added.