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GRASS PLANTS CAN TRANSPORT INFECTIOUS PRIONS
Grass plants can bind, uptake and transport infectious prions, according to researchers at The University of Texas Health Science Center at Houston (UTHealth). The research was published online in the latest issue of Cell Reports.
...Soto's team analyzed the retention of infectious prion protein and infectivity in wheat grass roots and leaves incubated with prion-contaminated brain material and discovered that even highly diluted amounts can bind to the roots and leaves. When the wheat grass was consumed by hamsters, the animals were infected with the disease. The team also learned that infectious prion proteins could be detected in plants exposed to urine and feces from prion-infected hamsters and deer.
Researchers also found that plants can uptake prions from contaminated soil and transport them to different parts of the plant, which can act as a carrier of infectivity. This suggests that plants may play an important role in environmental prion contamination and the horizontal transmission of the disease.
Chronic Wasting Disease (CWD) is a transmissible neurological disease of deer and elk that produces small lesions in brains of infected animals. It is characterized by loss of body condition, behavioral abnormalities and death. CWD is classified as a transmissible spongiform encephalopathy (TSE), and is similar to mad cow disease in cattle and scrapie in sheep. Infectious agents of CWD are neither bacteria nor viruses, but are hypothesized to be prions. Prions are infectious proteins without associated nucleic acids.
Prion diseases are a group of neurodegenerative diseases caused by prions, which are “proteinaceous infectious particles.” For some background, first see this introduction to prions. Prion diseases are caused by misfolded forms of the prion protein, also known as PrP. These diseases affect a lot of different mammals in addition to humans – for instance, there is scrapie in sheep, mad cow disease in cows, and chronic wasting disease in deer.
originally posted by: spirit_horse
This could mean that many lands and crops are being infected with prions. I read once that many cases of Alzheimers are actually misdiagnosed prion disease or vCJD (variant Creutzfeldt-Jakob disease). Scary thought.
Macrophages, especially follicular dendritic cells, contribute to the pathogenesis of prion diseases by accumulating an abnormal isoform of prion protein (PrPSc), which is converted from the cellular isoform of prion protein (PrPC). ...
originally posted by: soficrow
a reply to: rickymouse
Good post, thanks. But (there's always a but), remember that bit about how prions use the immune system to spread in the body? More here fyi:
Macrophages, especially follicular dendritic cells, contribute to the pathogenesis of prion diseases by accumulating an abnormal isoform of prion protein (PrPSc), which is converted from the cellular isoform of prion protein (PrPC). ...
Why couldn't you use bromelaine or another proteinase containing foods or supplements to destroy these misfolded proteins in the blood stream? When I drink milk, some proteins get through and just eating some fresh pineapple or grapefruit can take the headache and ugly feeling away.
It probably won't tough the ones embedded into our cells though. We make our own enzyme like pepsin that is supposed to do this, destroying the proteins in the body. Why isn't the body making that in response to the prions?
originally posted by: soficrow
a reply to: spirit_horse
Good post.
But never mind CWD - pharmaceutical manufacturing creates prions, and so our bodies in response, and it all gets dumped into our ground water and waterways, and gets taken up by our food crops.
FYI - I am not frightened by prions - I see them as the DEW-line for adaptation and evolution. BUT - we are changing our environment too much and too fast, and now we're in trouble. Thing is, we should be focusing on environmental clean-up, and stopping doing the things that create prions, not looking for a magical "cure." You can't "cure" a natural process, nor should you want to do so.
Molecular and cellular aspects of protein misfolding and disease
Proteins are essential elements for life. They are building blocks of all organisms and the operators of cellular functions. Humans produce a repertoire of at least 30,000 different proteins, each with a different role. Each protein has its own unique sequence and shape (native conformation) to fulfill its specific function. The appearance of incorrectly shaped (misfolded) proteins occurs on exposure to environmental changes. Protein misfolding and the subsequent aggregation is associated with various, often highly debilitating, diseases for which no sufficient cure is available yet. ...
Feeding on Prion-Contaminated Plants Sickens Animals
....A new study... indicates that grass plants bind prions. Also, stems and leaves from grass plants grown in infected soil contain prions. Finally, when prion-contaminated plant samples are fed to hamsters, the animals develop prion disease.
These findings appeared May 14 in Cell Reports, in an article entitled, “Grass Plants Bind, Retain, Uptake, and Transport Infectious Prions.” The article’s authors, who are based at the University of Texas Health Science Center at Houston, emphasized that there is no proof of transmission from wild animals and plants to humans. However, according to senior author Claudio Soto, Ph.D., the possibility “needs to be explored and people need to be aware of it.” Prions, he added, have a long incubation period.
...“These findings,” the researchers concluded in Cell Reports, “demonstrate that plants can efficiently bind infectious prions and act as carriers of infectivity, suggesting a possible role of environmental prion contamination in the horizontal transmission of the disease.”