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Ebola Whole Virus Vaccine Shown Effective, Safe in Primates
An Ebola whole virus vaccine, constructed using a novel experimental platform, has been shown to effectively protect monkeys exposed to the often fatal virus.
The vaccine, described today (March 26, 2015) in the journal Science, was developed by a group led by Yoshihiro Kawaoka, a University of Wisconsin-Madison expert on avian influenza, Ebola and other viruses of medical importance. It differs from other Ebola vaccines because as an inactivated whole virus vaccine, it primes the host immune system with the full complement of Ebola viral proteins and genes, potentially conferring greater protection.
…a significant challenge remains ahead to declare an end to the outbreak of the deadly Ebola virus that has killed more than 10,000 people in the three West African nations of Liberia, Guinea and Sierra Leone.
In a release issued in Monrovia on Monday, the MSF observed that more efforts have to be exerted to bring the Ebola crisis to an end as the number of cases weekly in West Africa is still higher than in any previous outbreak.
According to the release, the MSF statement is part of a critical analysis of the Ebola epidemic in West Africa over the past year, revealing the shortcomings of the global response to the crisis as well as warning that the outbreak, despite an overall decline in cases, is not yet over.
Wisconsin lab broke Ebola rules, watchdog group says
Sep 25, 2007 (CIDRAP News) – Researchers at the University of Wisconsin at Madison (UW-Madison) worked on Ebola virus genetic material in a lab that lacked the required security measures, and federal agencies responsible for monitoring compliance didn't notice the problem, a watchdog group that monitors biodefense research safety reported recently.
UW-Madison's institutional biosafety committee (IBC) wrongly allowed well-known influenza researcher Yoshihiro Kawaoka to work with Ebola genetic material in a biosafety level 3 (BSL-3) lab, though federal rules require use of a BSL-4 lab for such work, the Sunshine Project, based in Austin, Tex., reported on Sep 19. BSL-4 is the highest biosecurity rating.
The university stopped the research in October 2006 after the National Institutes of Health (NIH) said a BSL-4 lab was required, even though the university disagreed, according to UW-Madison officials. The NIH was funding the research.
…..The Web site for Kawaoka's lab says that in addition to work on influenza viruses, researchers are exploring the molecular pathogenesis of the Ebola virus and have established a reverse-genetics system for generating the virus, which they hope to use for vaccine production and the identification of antiviral medication targets.
The Web site emphasizes that the lab has developed a novel complement system that allows researchers to study Ebola virus glycoproteins without having to do the work in a BSL-4 lab.
Researcher sought lighter restrictions
The Sunshine Project's report makes it clear that Kawaoka and his colleagues weren't working with live Ebola virus, but rather full-length copies of Ebola DNA (complementary DNA, or cDNA) that lacks two critical proteins that could trigger growth of an infectious virus. However, the group says that federal rules require use of a BSL-4 lab for handling Ebola virus genetic material "that has not been rendered irreversibly incapable of reproducing."
…."He made the request based on facts that his colleagues at the CDC are working with the same material under BSL-2 conditions," he said. Kawaoka's lab is part of the veterinary school.
originally posted by: shaneslaughta
The question is, will they give this away worldwide to eradicate this menace from earth?
I doubt it, no profit in it.
originally posted by: butcherguy
Hopefully, if there is a mutation of the virus which makes it easily transmissible, the vaccine will still be effective.
originally posted by: Prezbo369
originally posted by: shaneslaughta
The question is, will they give this away worldwide to eradicate this menace from earth?
I doubt it, no profit in it.
No the question is would the anti-vaxers take this vaccination if ebola were to hit the west in force?
originally posted by: shaneslaughta
The question is, will they give this away worldwide to eradicate this menace from earth?
I doubt it, no profit in it.
originally posted by: rickymouse
I hope this remains open source. I bet Pharma companies will buy it somehow though. They will use donations to the institute to gain control of it or cut it down finding mild side effects and accentuating them even though their own vaccines hurt more people than this probably will.
originally posted by: Prezbo369
originally posted by: shaneslaughta
The question is, will they give this away worldwide to eradicate this menace from earth?
I doubt it, no profit in it.
No the question is would the anti-vaxers take this vaccination if ebola were to hit the west in force?
originally posted by: soficrow
originally posted by: Prezbo369
originally posted by: shaneslaughta
The question is, will they give this away worldwide to eradicate this menace from earth?
I doubt it, no profit in it.
No the question is would the anti-vaxers take this vaccination if ebola were to hit the west in force?
I know I would consider it (if Ebola went virulent and pandemic). Partly because I'm old and the worst effects show up in long term, and even though I no longer take vaccines because I've learned too much:
1. No one understands the human immune system well enough to know how to tinker with it, or to ensure that any tinkering is safe and effective;
2. Vaccines are well-known to be chock full of prions and misfolded proteins - some are created in the manufacturing process, while others result from contaminated components - not all cause disease, but no attempts are made to identify or filter out these potentially disease-causing molecules; and
3. Before vaccines, there was no way to fight epidemic viral diseases, and vaccines remain the only weapon in that arsenal - so I believe governments push vaccines only because they have nothing else to offer.
....AND ALSO, I happen to think Kawaoka puts human health first, and with Fouchier, is the most likely to solve the long term health issues.
originally posted by: BlueJacket
a reply to: Prezbo369
Considering this Virus has remained where it has its origins for thousands of years until very recently...Im not sure why we would want to vaccinate people in the West. I am happy with this discovery though as it really may help millions in Africa.
This whole anti-vaxxer appellation is misconstrued anyway...do you honestly believe the people who don't want to submit their children or selves to live vaccines and adjuvants etc...are against good safe medical technology and that they dont want the best for their families? The venom I feel from people who cant accept that people have good reason to be suspect because we have yet to isolate the cause behind a number of actual adverse effects from vaccines, is not founded in truth.
Back on topic, Thank you for bringing this to our attention Soficrow, I was unaware that of Kawaoka and his work, I now have a great deal of respect for his method and desire for Open Source. Thanks
In Guinea, patient numbers are again rising. In Sierra Leone, many people are presenting with the virus who were not previously on lists of known Ebola contacts. On 20 March, a patient tested positive for Ebola in Monrovia, the first confirmed case in more than two weeks after the last known case was discharged in Liberia.
originally posted by: BlueJacket
a reply to: Prezbo369
Considering this Virus has remained where it has its origins for thousands of years until very recently...Im not sure why we would want to vaccinate people in the West. I am happy with this discovery though as it really may help millions in Africa.
This whole anti-vaxxer appellation is misconstrued anyway...do you honestly believe the people who don't want to submit their children or selves to live vaccines and adjuvants etc...are against good safe medical technology and that they dont want the best for their families? The venom I feel from people who cant accept that people have good reason to be suspect because we have yet to isolate the cause behind a number of actual adverse effects from vaccines, is not founded in truth.
...I think the ignorance and arrogance of anti-vaxxers allow them to justify putting their families and loved ones at risk. They think that armchair 'research' and anecdotal tales and experience can take place of established science.
The venom you feel my stem from the fact that by refusing vaccinations you are potentially putting many others at risk. Which would of course be incredibly selfish.
Vaccines Harmful, Ineffective: Mainstream Studies
New studies from Canada, the US, Japan and Hong Kong support Canada's 2009 finding that seasonal flu vaccination almost doubled the risk of infection with pandemic flu - and does NOT provide higher protection than no vaccine. This information is being suppressed in the mainstream media, and most published public reports spin the info to minimize the data's importance and protect Big Pharma.
* Flu vaccines prevent children from building their natural immunity to other flu viruses. By comparison, a natural infection induces cross-immunity. This means that regularly vaccinated kids are sitting ducks in a pandemic - because they haven't built up their immunity.