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The University of Wisconsin-Madison has provided the first evidence of specific molecular changes in the body following a period of mindfulness meditation.
Researchers from Spain, France, and Wisconsin have reported that the effects of a single day of intensive mindfulness meditation can change our genes. The study, published in Psychoneuroendocrinology, showed that after eight hours of mindfulness practice, meditators showed a range of genetic expression changes, including altered levels of gene-regulating machinery and reduced levels of pro-inflammatory genes, which means that people could recover from stress and its physical ramifications much faster than previously thought possible.
“To the best of our knowledge, this is the first paper that shows rapid alterations in gene expression within subjects associated with mindfulness meditation practice,” says study author Richard J. Davidson, founder of the Center for Investigating Healthy Minds and the William James and Vilas Professor of Psychology and Psychiatry at the University of Wisconsin-Madison.
“Most interestingly, the changes were observed in genes that are the current targets of anti-inflammatory and analgesic drugs,” says Perla Kaliman, first author of the article and a researcher at the Institute of Biomedical Research of Barcelona, Spain (IIBB-CSIC-IDIBAPS), where the molecular analyses were conducted.
The analgesic drug market in the US alone amounts to over $2.3 billion annually for pharmaceutical companies like Proctor & Gamble, and that’s just for over-the-counter drugs. Simply practicing meditation could eliminate the need for expensive and side effect-causing medication that can ruin the body’s natural immune response.
Summary
Background
A growing body of research shows that mindfulness meditation can alter neural, behavioral and biochemical processes. However, the mechanisms responsible for such clinically relevant effects remain elusive.
Methods
Here we explored the impact of a day of intensive practice of mindfulness meditation in experienced subjects (n = 19) on the expression of circadian, chromatin modulatory and inflammatory genes in peripheral blood mononuclear cells (PBMC). In parallel, we analyzed a control group of subjects with no meditation experience who engaged in leisure activities in the same environment (n = 21). PBMC from all participants were obtained before (t1) and after (t2) the intervention (t2 − t1 = 8 h) and gene expression was analyzed using custom pathway focused quantitative-real time PCR assays. Both groups were also presented with the Trier Social Stress Test (TSST).
Results
Core clock gene expression at baseline (t1) was similar between groups and their rhythmicity was not influenced in meditators by the intensive day of practice. Similarly, we found that all the epigenetic regulatory enzymes and inflammatory genes analyzed exhibited similar basal expression levels in the two groups. In contrast, after the brief intervention we detected reduced expression of histone deacetylase genes (HDAC 2, 3 and 9), alterations in global modification of histones (H4ac; H3K4me3) and decreased expression of pro-inflammatory genes (RIPK2 and COX2) in meditators compared with controls. We found that the expression of RIPK2 and HDAC2 genes was associated with a faster cortisol recovery to the TSST in both groups.
Conclusions
The regulation of HDACs and inflammatory pathways may represent some of the mechanisms underlying the therapeutic potential of mindfulness-based interventions. Our findings set the foundation for future studies to further assess meditation strategies for the treatment of chronic inflammatory conditions.
Keywords
Mindfulness;
Meditation;
Epigenetics;
Inflammation;
HDAC;
Stress
originally posted by: AnarchoCapitalist
Cells display conscious decision making processes in reacting to their environment.
originally posted by: Ridhya
originally posted by: AnarchoCapitalist
Cells display conscious decision making processes in reacting to their environment.
Saying that cells are conscious because of a reaction is a crazy stretch. They dont CHOOSE to become a different tissue. But the article is interesting.
Meditating changes the chemical environment of all cells within a body. By meditating, we can take control over the emotional chemical soup that the brain is constantly generating.
If we assume all matter has some level of consciousness to it, then Lipton's findings make all the more sense.
originally posted by: Aphorism
Meditation, in the western sense, is a euphemism for focusing, thinking and perhaps calmly breathing.
Any basic exercise can alter the human body;
....there was no difference in the tested genes between the two groups of people at the start of the study. The observed effects were seen only in the meditators following mindfulness practice. In addition, several other DNA-modifying genes showed no differences between groups, suggesting that the mindfulness practice specifically affected certain regulatory pathways.
...the key result is that meditators experienced genetic changes following mindfulness practice that were not seen in the non-meditating group after other quiet activities
And I fully agree with you that if a person chooses (makes a conscious decision) to stand in an aggressive posture, they can alter the chemical behavior of their body. That only goes to prove my point, not disprove it.
The bottom line is that our cells respond to our conscious perceptions.
originally posted by: TruthxIsxInxThexMist
a reply to: AnarchoCapitalist
Can't watch this video now but maybe later.
I wonder if 'meditating' could help to cure my Mind. I have acute 'Schizophrenia' which means I am stable, calm but still hear things when around people.
I can try but 'Meditation' is something which one really needs to be able to continue doing regularly and I'm not sure I can sit still Meditating for long periods. I wonder if I focus on my Mind whether I can fix my Brain.