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Regrowing a fingertip cut off in an accident sounds like something from a futuristic movie. But with innovative technology developed by the U.S. Army, such regrowth is possible today.
Originally posted by dooper
The truth is, if you have an infant, and he/she gets a fingertip mangled, rather than try to "reconfigure" it, it is better to cut if off just above the first joint. A brand new, perfect fingertip will regrow.
Somewhere around age 1-2 years of age, this ability drops off.
In biophysics, the ability to stimulate cellular dedifferentiation (growing whatever cells are needed, in the right place, and in the right amount) can be accomplished using the same EM activity the body uses. Scalar EM excitation.
Our little group are not licensed medical practitioners, but we have accomplished some interesting physical activities by this EM stimulation.
Since we can only use this on ourselves, or let others use it on themselves legally, we've been somewhat limited in our experiments.
Reversed one case of lung cancer.
Reversed one case of leukemia.
Reversed on case of macular degeneration.
Eliminated a bad smoker's hack.
A friends elderly mother crushed and shattered her elbow, surgeon sewed bones back in relative order to enable swelling to go down so they could do an elbow replacement.
Gave this to her, pain immediately was gone, and elbow was completely healed and in perfect condition two weeks later. Doctors were stunned, but she was under an oath not to tell how this happened.
We note that we don't get sick. Nothing. Never any flu, cold, sore throats, nothing.
Granddaughter with fever of 101.4, terribly sick, bouncing around with normal temperature after three hours from exposure.
Yes, there is a way to stimulate cellular dedifferentiation, and do so without biology or chemistry. Simple biophysics.
How? Well that's the truly remarkable part. It wasn't a transplant. Mr Spievak re-grew his finger tip. He used a powder - or pixie dust as he sometimes refers to it while telling his story.
Mr Speivak's brother Alan - who was working in the field of regenerative medicine - sent him the powder.
For ten days Mr Spievak put a little on his finger.
"The second time I put it on I already could see growth. Each day it was up further. Finally it closed up and was a finger.
"It took about four weeks before it was sealed."
The Army's regenerative medicine study combined properties from the intestinal lining and the urinary bladder to create a regenerative substance called Extracellular Matrix.
The cream-colored crystallized powder, called "magic dust," boosts the body's natural tendency to repair itself, said U.S. Army Biological Scientist Sgt. Glen Rossman. When the matrix is applied to a missing digit or limb, "the body thinks it's back in the womb," Rossman said.
One civilian participated in the regenerative-medicine study after cutting off the tip of his finger in a model plane's propeller. Researchers continually applied the matrix to the wound, and after four weeks, the body grew skin and tissue to replenish the damaged area.
The Department of Defense announced the creation of the new, federally-funded institution, the Armed Forces Institute of Regenerative Medicine (AFIRM) during a briefing today at the Pentagon.
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“Therapies developed by the AFIRM project will greatly benefit wounded warriors, as well as the civilian population with, burns or severe trauma due to illness or injury,” said Dr. S. Ward Casscells, assistant secretary of defense for health affairs.
The AFIRM team is committed to developing clinical therapies over the next five years focusing on the following five areas:
· Burn repair
· Wound healing without scarring
· Craniofacial reconstruction
· Limb reconstruction, regeneration or transplantation
· Compartment syndrome, a condition related to inflammation after surgery or injury that can lead to increased pressure, impaired blood flow, nerve damage and muscle death
“Following in the great military medical tradition of innovation, collaboration and progressive research, AFIRM will unify and apply all the recent breakthroughs in regenerative medicine while leading the charge to new ones,” said Casscells.
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In addition to developing clinical treatments, the AFIRM will serve as a training facility to develop experts in treating trauma with regenerative medicine and will serve as a resource to help the military develop tissues as needs are identified.
Doctors from the U.S. Army Institute of Surgical Research are trying a regenerative medicine powder that’s already approved by the Food and Drug Administration in hopes of stimulating tissue growth in soldiers with missing extremities.
“The powder is FDA approved and is already being used for hernia repairs and other applications,” said Dr. Steven Wolf, chief and task area manager of clinical trials at ISR. “But it has never been used for this reason in people.”
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The “pixie dust” is far from magic. It is derived from pig bladder. To create what Wolf refers to as extracellular matrix, scientists take a mix of protein and connective tissue, “spin” it to remove the cells, and then mash the remaining material into a powder.
“When put onto open wound, it seems the body starts to regrow normal tissue,” Wolf said.
The theory is that when the powder is applied, circulating stem cells see the matrix, stop and differentiate into whatever they are near, Wolf said. For instance, if by a bone, then the cells become bone; if by a blood vessel, then they become a blood vessel; or if by a nerve, they become a nerve.
In other words, the regenerative medicine powder acts as a stop sign for stem cells, which are undifferentiated cells everyone has circulating throughout their blood stream.
Wolf likens the concept to regrowth of a severed tail in a salamander.
“You pull a tail off a salamander, and it regrows,” Wolf said. “The end of the tail forms what is called a blastema, and that blastema elongates. We think that’s what happens when we put this powder on.
“This process of growing your fingers has happened to you before, in your mother’s womb,” Wolf said. “The code is there, the DNA is there. What we’re trying to do is trick your body into doing that again.”
Vandre said doctors often are forced to remove limbs because they know that if they don’t, the injured servicemember would always be in excruciating pain, and unable to function normally. The Armed Forces Institute of Regenerative Medicine is working to find ways to improve chances of recovery and regeneration that would encourage doctors to keep damaged limbs in place.
“The idea is to use stem cells to put people back together and re-grow the cells that are damaged,” Vandre said. The scientists use adult stem cells from the actual patients in their research to minimize the likelihood of rejection.
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“If it doesn’t work, there is no downside,” Wolf said. “That’s why we’re testing it on fingers vs. legs. If we apply it to a leg amputee, the downside is the soldier won’t be able to walk for several months, and it may not work.”
Advances That Go Beyond Theory
In his lab at Wake Forest University, a lab he calls a medical factory, Dr. Anthony Atala is growing body parts.
Atala and his team have built, from the cell level up, 18 different types of tissue so far, including muscle tissue, whole organs and the pulsing heart valve of a sheep.
"And is it growing?" Andrews asked.
"Absolutely," Atala said, showing him, "All this white material is new tissue."
"When people ask me 'what do you do,' we grow tissues and organs," he said. "We are making body parts that we can implant right back into patients."