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How FDA Failures Contributed to the Opioid Crisis
Andrew Kolodny, MD
journalofethics.ama-assn.org...
In 2002, faced with evidence that opioid prescribing had risen beyond levels that could be clinically warranted, the FDA convened an advisory committee meeting of 10 outside experts and asked if the broad indication on opioid labels should be narrowed to prohibit marketing for common chronic pain conditions.16 Eight of these experts had financial ties to pharmaceutical companies, including Purdue,16 and advised the FDA against narrowing the indication. . 17 An opportunity to reign in overprescribing early in the crisis was lost, and, by 2013, enough opioids were prescribed to provide every adult in the country with a full pill bottle.18