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Memory can change the shape of a room; it can change the color of a car. And memories can be distorted. They're just an interpretation, they're not a record, and they're irrelevant if you have the facts.
Our internal states can color our memories just as powerfully as the external environment. A study finds that hippocampal GABAA receptors and associated microRNAs are important for generating state-dependent contextual fear memories.
What happens underwater stays underwater. Essentially, that was the conclusion of what became a classic study in psychology conducted some 40 years ago by Godden and Baddeley1. The two researchers somehow persuaded a group of divers, who were otherwise enjoying a relaxing holiday in Scotland, to learn a long list of simple words either when they were in the water or on land, and then asked them to freely recall the words in one or the other environment. As Godden and Baddeley had suspected, more words were recalled when the divers were in the same environment, wet or dry, in which they had originally learned them in. This phenomenon is now well-known in psychology as state-dependent learning2. It tells us that not only does the external environment direct what we learn and remember, but so too does the internal state of our body and mind. And this applies to all manner of memories. It might even apply to the kinds of memories that are indelibly linked to profoundly traumatic events that can spiral into an anxiety disorder or post-traumatic stress disorder. These disorders have become some of the most prevalent of all psychiatric conditions and place a heavy burden on individuals, their families and society at large. But, although we have been making appreciable progress in drawing an increasingly detailed schematic of the brain circuitry responsible for forming, storing and erasing fear memories3,4,5, we still know surprisingly little about how the brain processes information about state to modulate fear memories.
The other population, extra-synaptic GABA receptors, are independent agents. They ignore the peppy glutamate. Instead, their job is internally focused, adjusting brain waves and mental states according to the levels of internal chemicals, such as GABA, sex hormones and micro RNAs. Extra-synaptic GABA receptors change the brain’s state to make us aroused, sleepy, alert, sedated, inebriated or even psychotic. However, Northwestern scientists discovered another critical role; these receptors also help encode memories of a fear-inducing event and then store them away, hidden from consciousness.
“The brain functions in different states, much like a radio operates at AM and FM frequency bands,” Radulovic said. “It’s as if the brain is normally tuned to FM stations to access memories, but needs to be tuned to AM stations to access subconscious memories. If a traumatic event occurs when these extra-synaptic GABA receptors are activated, the memory of this event cannot be accessed unless these receptors are activated once again, essentially tuning the brain into the AM stations.”
I know factual pieces of the event that happened based on others around me telling me