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To date, no effective and specific therapeutic method can be used to treat patients suffering from SARS‐CoV infection. RNA interference (RNAi) is a process by which the introduced small interfering RNA (siRNA) could cause the degradation of mRNA with identical sequence specificity.
We constructed specific siRNAs targeting the S gene in SARS‐CoV. We demonstrated that the siRNAs could effectively and specifically inhibit gene expression of Spike protein in SARS‐CoV‐infected cells. [B]Our study provided evidence that RNAi could be a tool for inhibition of SARS‐CoV.
Recently, this technique was employed in anti‐virus infections in human immunodeficiency virus and hepatitis C/B virus...
Other groups reported that siRNA could specifically inhibit HIV‐1 replication and virus propagation [19] through targeting major genes in the HIV life cycle, including p24 (the HIV long terminal repeat)
MOV10 protein, a putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibits retrovirus replication. We show that MOV10 also severely restricts human LINE1 (L1), Alu, and SVA retrotransposons.
originally posted by: Wisenox
a reply to: Ksihkehe
The RNAi study is from 2004. They may have done studies. I'm not sure.
The difference with this one is that known ingredients and mechanisms of action exist. So, verification could be performed.
originally posted by: MapMistress
On autopsies of those that died of Covid, there is no Covid in the brain. Just some malfunctioning astrocytes and death of cells due to lack of oxygen.
Bolstering these lab studies, a group including Daniel Martins-de-Souza, head of proteomics at the University of Campinas in Brazil, reported6 in a February preprint that it had analysed brain samples from 26 people who died with COVID-19. In the five whose brain cells showed evidence of SARS-CoV-2 infection, 66% of the affected cells were astrocytes.