Infection-enhancing anti-SARSCOV2 antibodies recog both the orig Wuhan strain & Delta variants

This paper supports the development of antibody dependent enhancement related to the sarscov2 “vaccinations”.

Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination ?

Abstract:

Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.

pubmed.ncbi.nlm.nih.gov...

I pray this does not develop further, but displays the carelessness / recklessness that these “vaccines” are being pushed onto the entire population. Many prominent medical doctors and vaccine researchers such as world renowned vaccinologist Dr Bossche PhD, and Doctor Malone MD, have warned of this scenario as far back as March of this year. Supporting evidence can be found with proir animal trials for corona virus vaccine development, where some trials exhibited a 100% fatality rate all due to ADE.

This is more evidence supporting the need to halt the “vaccine” programs and to take a step back and evaluate the data. It is ethically irresponsible to continue vaccinating people until we know how this will play out —especially kids, who by all indications do not need these experimental medical treatments. The FDA cannot approve these medications until ADE and all other known risks are properly evaluated.

Which was to be expected.

The FDA contract with Pfizer clearly stated they could not make any conclusions on ADE because of lack of data. Thus they could with ease say nothing and pretend like the vaccine was going to be fine.

One problem in taking this so-called vaccine is that they don't know enough about the vaccine to authorize it outright and we know this, while "we" don't know enough about the vaccine to trust it to not kill us.

Ignorance is bliss. People still believe and trust this government.

originally posted by: CharlesT
One problem in taking this so-called vaccine is that they don't know enough about the vaccine to authorize it outright and we know this, while "we" don't know enough about the vaccine to trust it to not kill us.

Ignorance is bliss. People still believe and trust this government.

Thats something I will never understand Charles... not directly towards you, but people in general.

WHY DO YOU BELIEVE ANYTHING ANY POLITICIAN SAYS... REGARDLESS OF SIDE?!

Why are you stupid?
Why do you take their interpretation, exgerations and bull# instead of holding them accountable for their actions.

Why do you focus on what they say instead of what tjey actually do? (and I dont mean what they say they do or want you to believe they do.....)