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Exploration of graphene oxide as intelligent platform for cancer
vaccine†
We explored an intelligent vaccine system via facile approaches with both experimental and theoretical technique
based on the two-dimensional graphene oxide (GO). Without extra addition of bio/chemical stimulators, the microsized
GO imparted various immune activation tactics to improve the antigen immunogenicity. A high antigen adsorption was
acquried, and the mechanism was revealed to be a combination of electrostatic, hydrophobic, and π-π stacking
interactions. The "folding GO" acted as a cytokine self-producer and antigen reservoir and a particular autophagy, which
efficiently promoted the activation of antigen presenting cells (APCs) and subsequent antigen cross-presentation. Such
a "One but All" modality thus induced high level of anti-tumor responses in a programmable way and resulted in an
efficient tumor regression in vivo. This work may shed light on the potential use of new dimensional nano-platform in
the development of high-performance cancer vaccines.
Efficient Lymph Node-Targeted Delivery of Personalized Cancer Vaccines with Reactive Oxygen Species-Inducing Reduced Graphene Oxide Nanosheets
www.ncbi.nlm.nih.gov...
originally posted by: pr0ph3t
Nice write up, but I do personally have issues believing a government that can't even fix pot-holed roads can have such an elaborate and devastating plan. Just seems a little drastic is all.