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Whilst our understanding of infectious diseases and their prevention is now very different compared to in 1918, most of the countries acrossthe world face the same challenge today with COVID-19, a virus with comparable lethality to H1N1 influenza in 1918. Two fundamental strategies are possible2:
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Results
In the (unlikely) absence of any control measures or spontaneous changes in individual behaviour, we would expect a peak in mortality (daily deaths) to occur after approximately 3 months(Figure 1A). In such scenarios, given an estimated R0 of 2.4, we predict 81% of the GB and US populations would be infected over the course of the epidemic. Epidemic timings are approximate given the limitations of surveillance data in both countries: The epidemic is predicted to be broader in the US than in GB and to peak slightly later. This is due to the larger geographic scaleof the US, resulting in more distinct localised epidemics across states (Figure 1B)than seen across GB. The higher peak in mortality in GB is due tothe smaller size of the country andits older population compared with the US. In total, in an unmitigated epidemic, we would predict approximately 510,000 deaths in GB and 2.2 million in the US, not accounting for the potential negative effects of health systems being overwhelmed on mortality.
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Use. Quinine has been used for the treatment of malaria and associated febrile states, leg cramps caused by vascular spasm, internal hemorrhoids, varicose veins, and pleural cavities after thoracoplasty. Dosing. Quinine has been widely studied as an antimalarial, and has been used at doses of 325 mg to 1 g as the sulfate salt.
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Diseases that decimated New World populations included smallpox, chicken pox, bubonic plague, whooping cough, typhus, and malaria. An indirect consequence of the Columbian Exchange was the discovery of quinine which is an anti-malarial drug. Quinine is from the bark of the cinchona tree found in mountain forests of Bolivia, Peru, Colombia, and Ecuador. This present from the New World was not discovered until the 19th century.
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By the time Europeans reached and colonized the Andes the indigenous population already used the bark of the Cinchona tree (quinine) to treat malaria and other types of fever.
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originally posted by: HODOSKE
only problem is you would have to drink 20 liters of tonic water a day to get enough quinine to be effective. a reply to: ElectricUniverse