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Affording the medication will be tough but hopefully it'll all fall back into place.
originally posted by: bobs_uruncle
a reply to: NarcolepticBuddha
Checked your other threads. Are you sure you haven't been misdiagnosed and actually have pitirysis rubra Polaris? The only things that work with prp are drugs like soriatane, Accutane and methotrexate. Your condition sounds a lot like my father's, who has prp. Get an hla scan, if you come out 4b27 or 4b28 positive, you likely have an aberrant immune system. You can also have them check for a P53 protein flag in skin samples.
BTW, is the redness symmetrical on the left and ride sides?
Cheers - Dave
originally posted by: rickymouse
originally posted by: bobs_uruncle
a reply to: NarcolepticBuddha
Checked your other threads. Are you sure you haven't been misdiagnosed and actually have pitirysis rubra Polaris? The only things that work with prp are drugs like soriatane, Accutane and methotrexate. Your condition sounds a lot like my father's, who has prp. Get an hla scan, if you come out 4b27 or 4b28 positive, you likely have an aberrant immune system. You can also have them check for a P53 protein flag in skin samples.
BTW, is the redness symmetrical on the left and ride sides?
Cheers - Dave
methotrexate is used to treat autoimmune issues too. It is anti-folate and blocks the uptake of some nutrients from the digestive system. I am not fond of how it works, there must be a better way than that. I think, but am not positive, that it blocks calcium channels too. That would lower the ability of the immune system to function well. Limiting calcium in the diet would do the same thing.
Neurontin works by increasing gaba and inhibiting calcium channels. Taurine moderates calcium channels and also increases GABA. Taurine is cheap, less than the copay on the meds. If you are hypoglycemic you have to watch taurine, it increases the uptake of insulin at cell receptors and also it also lowers lipids in the blood because of it's activity in the bile. It can lower the lipids too low for those on meds for diabetis or those who naturally produce too much insulin.
I haven't studied the two other meds you listed yet, I know a lot about the method of action of classes of drugs, not necessarily by brand name.
originally posted by: bobs_uruncle
originally posted by: rickymouse
originally posted by: bobs_uruncle
a reply to: NarcolepticBuddha
Checked your other threads. Are you sure you haven't been misdiagnosed and actually have pitirysis rubra Polaris? The only things that work with prp are drugs like soriatane, Accutane and methotrexate. Your condition sounds a lot like my father's, who has prp. Get an hla scan, if you come out 4b27 or 4b28 positive, you likely have an aberrant immune system. You can also have them check for a P53 protein flag in skin samples.
BTW, is the redness symmetrical on the left and ride sides?
Cheers - Dave
methotrexate is used to treat autoimmune issues too. It is anti-folate and blocks the uptake of some nutrients from the digestive system. I am not fond of how it works, there must be a better way than that. I think, but am not positive, that it blocks calcium channels too. That would lower the ability of the immune system to function well. Limiting calcium in the diet would do the same thing.
Neurontin works by increasing gaba and inhibiting calcium channels. Taurine moderates calcium channels and also increases GABA. Taurine is cheap, less than the copay on the meds. If you are hypoglycemic you have to watch taurine, it increases the uptake of insulin at cell receptors and also it also lowers lipids in the blood because of it's activity in the bile. It can lower the lipids too low for those on meds for diabetis or those who naturally produce too much insulin.
I haven't studied the two other meds you listed yet, I know a lot about the method of action of classes of drugs, not necessarily by brand name.
Imuran is another one like methotrexate, but even pricier. If you want to check on the users mailing list for prp, it HERE. You can get a lot of info from the archived and current mailing lists on this rather rare form of auto-immune disease. When my father got it he turned symmetrically red with very bad flaking of the skin, his hair turned white and his eyes changed from brown to blue, was very strange. The prp seemed to be a p53 triggered flag that was indicative of the bowel cancer he was developing. He had surgery, removed the cancer and went into prp remission. The cancer was however still in his system, cells were in his blood and lymph nodes. When he got liver cancer, the prp came back. He had a second surgery removing the liver cancer and again the prp went into remission. About 3 years ago the cancer moved again and they found nodes on his lungs. We caught it fast though and blocked the cancers, thereby blocking a new recurrence of prp.
I have only second hand experience with prp (father and uncle), but our family is hla 4b27 positive, so my brothers and I have to deal with ankylosing spondylitus, uvietis and iritis. Methotrexate is a viable solution to reset the auto-immune system if monitored properly for liver and other issues.
Cheers - Dave
originally posted by: MerleWoods
a reply to: NarcolepticBuddha
i missed the first 2 parts thanks