Injectable Insulins are Amyloidogenic

a reply to: rickymouse

Don't worry. I am about to share with ya'll a compilation of information on The Endocannabinoid System and Diabetes. Today. Then it will be Alzheimer's. Then maybe the skin.

Updated references and info:

1. Localized Amyloidosis at the Site of Repeated Insulin Injection in a Diabetic Patient

www.jstage.jst.go.jp...

2. Progressive insulin-derived amyloidosis in a patient with type 2 diabetes

www.ncbi.nlm.nih.gov...

3. Insulin-derived Amyloidosis and Poor Glycemic Control: A Case Series

www.amjmed.com...(14)00035-7/fulltext

4. Localized insulin-derived amyloidosis: A potential pitfall in the diagnosis of systemic amyloidosis by fat aspirate

onlinelibrary.wiley.com...

5. Localized insulin-derived amyloidosis in patients with diabetes mellitus: a case report

www.humanpathol.com...(09)00167-1/abstract

6. Cutaneous amyloidosis at the site of insulin injection with coexistence of acanthosis nigricans

www.ijpmonline.org...

7. Insulin Derived Amyloidosis

www.ncbi.nlm.nih.gov...

8. Ultrasonography Improves Glycemic Control by Detecting Insulin-Derived Localized Amyloidosis

www.umbjournal.org...(17)30279-X/pdf

9. A Case of Insulin Resistance Secondary to Insulin Induced Localized Cutaneous Amyloidosis.

www.bloodjournal.org...

10. Amyloidoma secondary to insulin injection: Cytologic diagnosis and pitfalls

www.ncbi.nlm.nih.gov...

11. Localized insulin amyloidosis with use of a concentrated insulin: a potential complication

onlinelibrary.wiley.com...

12. Nodular amyloidosis at the sites of insulin injections

onlinelibrary.wiley.com...

13. Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis

www.sciencedirect.com...

14. A Case of Type 1 Diabetes Mellitus with Marked Poor Glycemic Control caused by Insulin-derived Amyloidosis at the Site of Repeated Insulin Injections

www.jstage.jst.go.jp...

15. Coexistence of insulin-derived amyloidosis and an underlying acanthosis nigricans-like lesion at the site of insulin injection

onlinelibrary.wiley.com...

16. Localized insulin-dependent amyloidosis with scar tissue formation

www.jaad.org...(14)01680-6/pdf

17. Iatrogenic, insulin-dependent, local amyloidosis.

www.ncbi.nlm.nih.gov...

18. Pharmaceutical amyloidosis associated with subcutaneous insulin and enfuvirtide administration

www.ncbi.nlm.nih.gov...

19. The association between injected insulin and diffused cutaneous amyloidosis

www.mmh.org.tw...

20. Generating local amyloidosis in mice by the subcutaneous injection of human insulin amyloid fibrils

www.spandidos-publications.com...

21. AN ATYPICAL PRESENTATION OF INSULIN AMYLOIDOSIS: AN UNCOMMON BUT IMPORTANT COMPLICATION OF INSULIN THERAPY

journals.aace.com...

22. Rapid degradation kinetics of amyloid fibrils under mild conditions by an archaeal chaperonin

www.ibbr.umd.edu...

23. Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus

www.hindawi.com...

24. New Histologic Finding of Amyloid Insulin Bodies at an Insulin Injection Site in a Patient With Diabetes

www.ncbi.nlm.nih.gov...

25. Human recombinant insulin and amyloidosis: an unexpected association

www.njmonline.nl...

26. Nodular amyloidosis in a diabetic patient with frequent hypoglycemia: Sequelae of repeatedly injecting insulin without site rotation

www.jaad.org...(10)00257-4/pdf

27. Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient

link.springer.com...

28. Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

www.tandfonline.com...

originally posted by: CJCrawley
a reply to: M4ngo

Apologies, I'm no expert.

But, as a nurse, I've never known anyone with T2D to inject insulin.

Apparently it is sometimes necessary but it's rare. In Britain anyway.

It may be due to obesity levels in the US.

We're very much bronze medalists when it comes to obesity.

My husband has type 2, and he ended up with a doctor who put him on insulin even though his Janumet, a metformin hybrid of sorts, was working fine. The insulin injections were extremely painful, burning at the injection spot, and it pushed his blood sugar way up. The more insulin, the more dangerously it rose.
He changed doctors, told the new doc what worked, he's back on the Janumet, and his sugar levels are back to perfect, and partly controlled by diet.

a reply to: snowspirit

How does he know his glucose levels are perfect? Does he have a CGM? I bet he still has postprandial hyperglycemia all the time. Janumet doesn't address the underlying problem of beta cell failure and loss of the first-phase insulin response, it just puts a bandaid on the issue until it gets worse.

a reply to: M4ngo

Perfect is an exaggeration a bit, but he tests daily, and goes for the lab tests - A1C and other basics. It does fluctuate wildly, but it's controlled on the low side better. It's the numbers that are perfect, not how it behaves. He keeps glucose tablets nearby in case it drops too low.

Nearly two years since I started this thread and on January 14th FDA released a new report on Potential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System, and cutaneous amyloidosis is listed and FDA is evaluating the need for regulatory action.

www.fda.gov...