Immune cell's role in intestinal movement may lead...

((The title of the article is long so I didn't include all of it in the title of this thread.))

Immune cell's role in intestinal movement may lead to better understanding of irritable bowel syndrome

Learning the role of immune-system cells in healthy digestive tracts and how they interact with neighboring nerve cells may lead to new treatments for irritable bowel syndrome (IBS). Researchers from Penn State College of Medicine, in collaboration with other scientists, have reported the role of macrophages in regulating the contractions of the colon to push digested material through the digestive tract.

The muscular lining of the intestine contains a distinct kind of macrophage, an immune system cell that helps fight infections. The role of these cells in normal colon function is not known, although they have been linked to inflammation after abdominal surgery.

"Very little is known about the function of muscularis macrophages, mainly because these cells are difficult to isolate from intestinal tissue," said Milena Bogunovic, assistant professor of microbiology and immunology.

Digested material is moved through the intestines by the contraction and relaxation of intestinal muscles. The pattern and frequency of these contractions are controlled by the signals from the intestinal nervous system. In patients with diseases like IBS, the signals are overactive and stimulation is exaggerated.

The researchers developed a method to deplete muscularis macrophages in the intestines of mice to determine their function. They report their findings in the journal Cell.

"After macrophage depletion, we observed that the normal intestinal movements are irregular, probably because the muscular contractions were poorly coordinated, suggesting that intestinal movements are regulated by macrophages," Bogunovic said

IBS ((Irritable Bowel Syndrome)) is something that roughly 20% of North Americans suffer from but that's just a guesstimate.
In the article it talks about how a potential cause of IBS is a change in the bacterial environment in the intestine. What exactly causes that change we don't know but there might be a link between GMO & IBS, at least that's what the American Academy of Environmental Medicine (AAEM) believes.

the American Academy of Environmental Medicine (AAEM), an international organization of physicians, says that there are serious health risks associated with eating GM foods, including infertility, immune system problems, accelerated aging, disruption of insulin and cholesterol regulation, gastrointestinal problems, and organ damage. “There is more than a casual association between GM foods and adverse health effects. There is causation,” as defined by recognized scientific criteria, the academy concluded.

Say No to GMO

Currently I've been labeled as a person with IBS because my doctor & my gastroenterologist don't know what is wrong with me. I started having problems 3yrs ago after my gall bladder was removed because of a large gall stone. Since then I've been having horrible problems with my intestines and eating. From all that we know about GMO & how it messes with the RNA of plants, animals & humans, it wouldn't surprise me if it was one of the leading causes of IBS & other gastrointestinal problems.

If IBS is because of a change in the bacterial environment of the intestine, I could see GMO being one of the causes for that change. It's not the only but it can not be ruled out.

Hopefully this research will lead to more of an understanding of these bacterias and maybe one day lead to a better treatment, if not a cure, for IBS

a reply to: knoledgeispower


What your going through is normal , my mother and good friend both had the same issue after getting their gal bladder removed.


They just can't pucker the same anymore ...... When its time to go its time to go.



Also my step grandma had chrones (not sure about the spelling)

She ended up having a fecal transplant (sounds nasty I know)

Basically they put someone's intestinal bacteria in her and it worked!

No more IBS or chrones

originally posted by: LightningStrikesHere

She ended up having a fecal transplant (sounds nasty I know)

On topic.
I've known two people who suffered from IBS who were completely cured by eating only organic food. While I believe organic food is more healthy, In the case of these two people it also meant they had cut out all the rubbish from their diet so that too may have helped them be cured.

a reply to: knoledgeispower

You need to supplement with enzymes. Your body no longer produces bile salts, which break down fat, so now your small intestines are working overtime to do the job your gall bladder was supposed to do. I'm sure your doctor never told you you'd need to take this for the rest of your life, or at all for that matter.

Probiotics will help. Fish oil will help repair the intestinal lining. Turmeric and Ginger are anti-inflammatory to put the fire out in your small intestines.

originally posted by: LightningStrikesHere
a reply to: knoledgeispower


What your going through is normal , my mother and good friend both had the same issue after getting their gal bladder removed.


They just can't pucker the same anymore ...... When its time to go its time to go.



Also my step grandma had chrones (not sure about the spelling)

She ended up having a fecal transplant (sounds nasty I know)

Basically they put someone's intestinal bacteria in her and it worked!

No more IBS or chrones

It is normal to have issues after your gall bladder has been removed because your liver just sends the same amount of bile as before, there is just no gall bladder to filter it into your body. However, that's not the case with me. Sure I couldn't eat for 2 months after the surgery but the problems I've been having is more than what it normal after surgery. ((According to 4 different doctors & a dietician)) My Mom has Crohn's and my younger sister has Sjogren's Syndrome, both disease are auto-immune so the doctors are thinking that the gall bladder surgery exacerbated something that was dormant before the surgery. I have lots more symptoms but until I get a diagnoses they have labeled me IBS & try to treat that part.

She ended up having a fecal transplant (sounds nasty I know)

Basically they put someone's intestinal bacteria in her and it worked!

No more IBS or Crohn's

Makes sense that it worked from what I read in the study I posted. Your Grandma's intestinal bacteria was out of whack and having new intestinal bacteria put into her worked.

originally posted by: VoidHawk

originally posted by: LightningStrikesHere

She ended up having a fecal transplant (sounds nasty I know)

On topic.
I've known two people who suffered from IBS who were completely cured by eating only organic food. While I believe organic food is more healthy, In the case of these two people it also meant they had cut out all the rubbish from their diet so that too may have helped them be cured.

I have a strict diet too. No greasy foods, nothing high in sugar or fat, no spicy foods, little to no onions, little to no garlic. That being said, there are times when foods that normally are fine in my body suddenly cause problems. It makes it frustrating but because I eat great, I've lost 40lbs in the three years since my gall bladder surgery.

a reply to: knoledgeispower

Interesting. ......fyi - the underlying problem is inflammation, whatever the trigger(s) - try to treat the inflammation to block the immune-neuron cascade and prevent fibrosis. Turmeric is excellent, plus cinnamon and psyllium. And don't forget ginger.

originally posted by: zardust
a reply to: knoledgeispower

You need to supplement with enzymes. Your body no longer produces bile salts, which break down fat, so now your small intestines are working overtime to do the job your gall bladder was supposed to do. I'm sure your doctor never told you you'd need to take this for the rest of your life, or at all for that matter.

Probiotics will help. Fish oil will help repair the intestinal lining. Turmeric and Ginger are anti-inflammatory to put the fire out in your small intestines.

That's what the dietician told me but I with all my other medications I'm on & the fact that I can't work, there is no way I can afford to take Probiotics on top of the multi vitamins I have to take. I had to pick and chose which medications to go on based on what I can afford and there are some that I can't afford.

My intestines look great so for the time there is no repairs that need to be done on my intestinal lining.
As for turmeric, I think that might do more harm than good. I take buscopan when I have bad intestinal cramping and it works right away. I did take aloe vera gel for a time and that helped but I had to tighten my purse strings so I can't take it anymore.

Thank you for your suggestions though.

originally posted by: soficrow
a reply to: knoledgeispower

Interesting.

......fyi - the underlying problem is inflammation, whatever the trigger(s) - try to treat the inflammation to block the immune-neuron cascade and prevent fibrosis. Turmeric is excellent, plus cinnamon and psyllium. And don't forget ginger.

I can't handle cinnamon at all, it hurts my body way too much. As I had just posted (so you didn't have time to read it) Turmeric will probably have the same effect on my body as cinnamon & I can not afford psyllium.

a reply to: knoledgeispower

Turmeric is worth testing - and psyllium is still cheap in the bulk food stores. Generic brands are cheaper than brand names too. ...I'd say you can't afford NOT to get it....

PS. Never, never take this stuff straight - ALWAYS mix it into your food! I add my "doses" to smoothies.

originally posted by: soficrow
a reply to: knoledgeispower

Turmeric is worth testing - and psyllium is still cheap in the bulk food stores. Generic brands are cheaper than brand names too. ...I'd say you can't afford NOT to get it....

PS. Never, never take this stuff straight - ALWAYS mix it into your food! I add my "doses" to smoothies.

It may be cheap but I just can't fit it into my budget. I have 0 wiggle room right now and I won't until I can figure out a way to be working from home in a legit business. I'm working with a job counselor who specializes in creating jobs for people with illnesses. She goes around to employers and basically says "Hey this is the person I have, is there a way you can use her". I had been hoping to do the Medical Transcription course so I can do that for a living but I have to get help from Work BC to pay for it and if for some reason I am unable to complete the course (most likely due to a flare up with my health) then I would have to pay back $5,000 and that is a gamble I just can't take.

The dietician I met with did tell me that it's best to put into smoothies so when I do have the money for psyllium & smoothies, I will be doing that. I will try turmeric and hope it doesn't cause me pain cause if it does, hells to the no I'm not putting myself through more pain in the hopes that it helps me in the long run.


On topic: I wonder if fecal transplants is how the doctors/scientists doing this study were able to come up with the idea for it?

I also take buscopan time to time for similar problems. I react to turmeric well but it doesn't end inflammation.
In my case some old candida is probably the source which developed on top of heavy metal poisoning (mercury from teeth 20 years ago). However, Lufenuron helped the candida problems immensely, just two or three treatments in a year.
Another thing - I don't know if it's available in some form abroad - is a form of native baked white tufa (mineral earth) in Hungary which is quite cheap and you can mix it into water. A few spoonfuls in the evening will sedate inflammation. The brand name's Neurosan I'm sure it exists in other countries. (GERD specialists would find it's a panacea).

a reply to: knoledgeispower

Triphala also works wonders for colon/digestive support. I don't have my gallbladder anymore and Triphala helps immensely. Also, I've noticed that spicy food works to reduce the output of bile.

a reply to: knoledgeispower

Probiotics doesn't need to be expensive. Try making your own sauerkraut or kimchi. It takes a week or 2, but it's very easy, cheap (think 1 cabbage and some salt) and probably better for you than non-food based probiotics.

I love the little book 'wild fermentation' by Sandor Katz. It's a book you have to put down every few pages....and rush to the kitchen to try what he just said. Opened my eyes to the real meaning of 'culture'!

originally posted by: MystikMushroom
a reply to: knoledgeispower

Triphala also works wonders for colon/digestive support. I don't have my gallbladder anymore and Triphala helps immensely. Also, I've noticed that spicy food works to reduce the output of bile.

Spicy foods have me running to the bathroom between 1-5mins, usually right away. It also causes me horrible pains.

a reply to: knoledgeispower

Well that's it then - only a magic pill or a life on disability will do the trick. Good luck.

originally posted by: soficrow
a reply to: knoledgeispower

Well that's it then - only a magic pill or a life on disability will do the trick. Good luck.

A proper diagnoses is what I need. The doctor even thinks it might be a bacterial infection from my gall bladder surgery & that just made me super mad that he, the gastro specialist & the doctor that performed my surgery never thought of that until now. You would think 3yrs ago when I was first starting to have problems that they would have done the test for that. Now I'm waiting for the right kind of sickness to hit me so they can do the most accurate test to see if that's what it is or not.

I don't take a magic pill but I take a medicinal plant that helps a great deal with not just my IBS stuff but all my other health issues.

I have also been outraged why doctors won't take cultures - it was years of suffering already.
A lot of them just won't listen. I had the same issue about dental and sinus problems until I found one doctor that actually listened to where it was hurting...

I hit upon the solution on the physical side in my own case, my gallbladder is still in but I cannot work normal hours. I can't go to sleep until I went to the bathroom a couple of times around 2-4 am. Then about 4-6 hrs later I am awake with a belly giving out strange noises and some pressure on the right side.

In my case, hot spices do not have any bad effect, in fact I would not have appetite frequently if I did not take some chili or ginger.

Another thing is: I worked years in holistic therapy, and I like to look at both sides of the issue, external/material and psychological/spiritual. In my case it helped some when I asked myself - and let only my deeper unconscious parts answer, not my surface chattering mind - if deep inside I connected this problem to any issue?

Then - if there is anything I could experience as far as inner terms, beliefs, relationship to the material environment go, that could improve the issue?

I wouldn't go further thatn that, but these careful first steps would be perhaps helpful. Or not - but they were in my case.