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In the case study of an Italian family where of 288 relatives over 6 generations, 29 are affected by the disorder. The average age of onset of the disease is 49, but this may vary with the individual as with one female who was 61 years of age. Her disease lasted 18 months and followed the following pattern of the disease.
There are four stages of the disease before an individual's life ends. The first stage is progressive insomnia, the trade mark of fatal familial insomnia. The first stage develops over approximately four months and includes a collection of psychiatric problems such as panic attacks and bizarre phobias. The second stage includes hallucinations, panic, agitation and sweating and lasts about five months. The third stage lasts about three months and is total insomnia with weight loss. The individual at this point looks much older and may experience incontinence. The fourth stage is around six months long and is recognized as dementia, total insomnia and sudden death after becoming mute.
Originally posted by Jonna
There is a movie that appears to be interesting called The Machinist which is about this topic.
Originally posted by Dr Love
Originally posted by Jonna
There is a movie that appears to be interesting called The Machinist which is about this topic.
Looks like a damn good flick!
Fatal Familial Insomnia
by: Ann M. Akroush
Fatal familial insomnia is a genetic disorder. It manifests itself by many symptoms due to the degeneration of a certain part of the brain, the thalamus. The disease also results in the formation of amyloid plaques. This is the build up of a waxy substance made of proteins associated with polysaccharides.
www-personal.umd.umich.edu...
The formation of amyloid plaques and neurofibrillary tangles are thought to contribute to the degradation of the neurons (nerve cells) in the brain and the subsequent symptoms of Alzheimer's disease.
AMYLOID PLAQUES
One of the hallmarks of Alzheimer's disease is the accumulation of amyloid plaques between nerve cells (neurons) in the brain. Amyloid is a general term for protein fragments that the body produces normally. Beta-amyloid is a fragment of a protein that is snipped from another protein called amyloid precursor protein (APP). In a healthy brain, these protein fragments would be broken down and eliminated. In Alzheimer's disease, the fragments accumulate to form hard, insoluble plaques.
NEUROFIBRILLARY TANGLES
Neurofibrillary tangles consist of insoluble twisted fibers that are found inside of the brain's cells. They primarily consist of a protein called tau, which forms part of a structure called a microtubule. The microtubule helps transport nutrients and other important substances from one part of the nerve cell to another. In Alzheimer's disease, however, the tau protein is abnormal and the microtubule structures collapse.
www.ahaf.org...
Originally posted by BillyD
I know hitler did a lot of testing on sleep deprivation on the Jews. The ethics of using that research is a big debate, however. I thought I remeber seeing about a week before your immune system crashes. There's pretty mixed reports about the psychological effects. As a college student I regularly go without sleep, so I've researched this area a bit. Apparently green tea will stave the negative effects on the immune system, but not for long.
As far as the three to four hours a night of sleep, it's not unhealthy. Ben Franklin taught himself to sleep four hours a night. The amount of sleep you need varies fro mperson to person.