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(Nanowerk News) Light microscopes based on scattering, reflection and absorption, or a combination of these, have been a key enabling technology for the study of objects invisible to our eyes, especially in the field of biology. Many improvements have been made in the past to create state-of-the-art techniques capable of achieving unprecedented resolution and sensitivity albeit their cost, which drastically increases with quality and versatility, making them quite unavailable for general applications.
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The researchers have developed a large FOV interferometric on-chip lens free microscope (LIM) based on a novel design with a very high axial sensitivity and DOF, applying a technique adequate to be used in microarray platforms for the detection of proteins without the need of labels.
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By using collimated polarized light, the team of scientists was able to reconstruct the image by shining light through the transparent sample to observe and analyze the phase shift and interference intensity pattern, a technique known as phase-shifting interferometry (PSI). As UPC Prof at ICFO Juan P. Torres states, "any slight refractive index change introduced by an impurity in the sample is translated into a phase difference and thus an intensity variation in the pattern, showing the contours and therefore size of the irregularity".
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